INT155087

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PBX2) transcription factor binding (PBX2)
Anatomy Link Frequency
B-cell 1
PBX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 7 86.80 High High
methadone 1 64.28 Quite High
addiction 2 48.60 Quite Low
tolerance 2 48.00 Quite Low
Disease Link Frequency Relevance Heat
Leukemia 1 100.00 Very High Very High Very High
Apoptosis 9 99.98 Very High Very High Very High
Death 5 84.68 Quite High
Recurrence 2 51.12 Quite High
Opiate Addiction 1 45.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the intrinsic pathway, the pro-apoptotic mitochondrial proteins Bax (Bcl-2-associated X protein) and AIF (apoptosis-inducing factor) remained unchanged, but cytochrome c was decreased (all addicts: 25%; ST: 31%; LT: 20%) and anti-apoptotic B-cell leukemia 2 (Bcl-2) increased in LT addicts (24%).
Positive_regulation (increased) of B-cell leukemia 2 in B-cell associated with leukemia and apoptosis
1) Confidence 0.15 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 1.19 Pain Relevance 0.41

General Comments

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