INT155090

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
brain 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 7 98.76 Very High Very High Very High
tolerance 2 83.28 Quite High
cytokine 14 57.40 Quite High
Inflammation 20 52.88 Quite High
Neuropeptide 7 50.00 Quite Low
methadone 1 47.20 Quite Low
Kinase C 6 33.20 Quite Low
addiction 2 31.52 Quite Low
cINOD 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 29 99.92 Very High Very High Very High
Apoptosis 73 98.72 Very High Very High Very High
Leukemia 1 83.52 Quite High
Repression 3 72.64 Quite High
Neuroblastoma 3 62.84 Quite High
Cancer 23 55.84 Quite High
INFLAMMATION 18 52.88 Quite High
Breast Cancer 2 50.64 Quite High
Colon Cancer 43 50.00 Quite Low
Recurrence 2 34.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
affected cell proliferation by inducing expression of p21, and cell death by influencing various Bcl-2 family proteins and caspase-3 activation.
Regulation (influencing) of Positive_regulation (activation) of Bcl-2 associated with death
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.30 Pain Relevance 0.06
In contrast, no significant changes in BCL2 protein levels were detected at 0, 24, or 72 h in the empty vector-transfected cells with or without miR-34a inhibition (Figure 9B, bottom panel).
Neg (no) Regulation (changes) of Neg (no) Positive_regulation (changes) of BCL2
2) Confidence 0.21 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.66 Pain Relevance 0
Instead, the chronic modulation of some of their components (downregulation of FADD and cytochrome c; upregulation of FLIP(L) and Bcl-2) suggests the induction of non-apoptotic actions by opiate drugs related to phenomena of synaptic plasticity in the brain.
Regulation (modulation) of Positive_regulation (upregulation) of Bcl-2 in brain associated with opiate and apoptosis
3) Confidence 0.16 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 0.82 Pain Relevance 0.49

General Comments

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