INT155091

Context Info Confidence 0.63 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 13.34 Pain Relevance 3.15

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1) intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)

Anatomy Link Frequency cleavage 10 hepatocytes 1 poly 1 cardiomyocytes 1 MCF-7 1 PARP1 (Homo sapiens)

Pain Link Frequency Relevance Heat opiate 7 99.28 rheumatoid arthritis 41 98.48 qutenza 14 97.92 metalloproteinase 12 97.48 aspirin 10 91.12 adenocard 3 90.24 Osteoarthritis 21 87.36 Arthritis 27 81.84 COX-2 inhibitor 3 81.40 cINOD 15 80.48

Disease Link Frequency Relevance Heat Apoptosis 362 99.80 Cancer 224 99.00 Rheumatoid Arthritis 41 98.48 Breast Cancer 23 97.48 Leukemia 7 96.08 Stress 69 95.76 Heart Disease 7 93.60 Necrosis 12 92.04 Osteoarthritis 21 87.36 Death 65 87.08

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FasL and TRAIL expression was confirmed by immunohistology and PARP cleavage was significantly associated with degeneration (P=0.027).

Localization (cleavage) of PARP in cleavage

1) Confidence 0.63 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.59 Pain Relevance 0.06

The content of executioner caspase-3 and the pattern of cleavage of the nuclear enzyme poly-(ADP-ribose)-polymerase-1 (PARP-1) were similar in opiate addicts and control subjects.

Localization (cleavage) of PARP-1 in cleavage associated with opiate

2) Confidence 0.56 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 1.11 Pain Relevance 0.47

Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.

Localization (cleavage) of PARP in MCF-7 associated with breast cancer and apoptosis

3) Confidence 0.47 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26

Importantly, apoptosis was synergistically induced by the combination treatment, as evidenced by caspase-3 activation and PARP cleavage.

Localization (cleavage) of PARP in cleavage associated with apoptosis

4) Confidence 0.42 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.98 Pain Relevance 0.49

In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.

Localization (cleavage) of PARP in cleavage

5) Confidence 0.42 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.88 Pain Relevance 0.44

In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.

Localization (cleavage) of poly-ADP ribose polymerase in cleavage

6) Confidence 0.37 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.89 Pain Relevance 0.45

In contrast, radiation up to 10 Gy was not sufficient to induce significant PARP-cleavage (Fig. 9C and data not shown).

Localization (cleavage) of PARP in cleavage

7) Confidence 0.36 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 0.98 Pain Relevance 0

Membranes were blocked with 5% milk in TBS containing 0.1% Tween 20, and incubated with antibodies specific for caspase 8 (Abcam), caspase 9, PARP, Snail (Cell Signaling Technology), pGSK3?

Localization (caspase) of PARP

8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0

Same amounts of cell extract were resolved by polyacrylamide gel electrophoresis and PARP cleavage was assessed by Western blotting.

Localization (cleavage) of PARP in cleavage

9) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.07 Pain Relevance 0.07

PARP can also be cleaved in the nucleus of cardiomyocytes through the action of matrix metalloproteinase 2 (MMP-2) [58], known to be activated by ONOO?

Localization (cleaved) of PARP in cardiomyocytes associated with metalloproteinase

10) Confidence 0.09 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.05 Pain Relevance 0.08

exerts potent proapoptotic effects in cardiomyocytes in vitro and in the myocardium in vivo, characterized by the activation of caspase-3 and the cleavage of PARP.

Localization (cleavage) of PARP in cleavage

11) Confidence 0.08 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.70 Pain Relevance 0.08

The authors added that PARP cleavage as a consequence of ONOO?

Localization (cleavage) of PARP in cleavage

12) Confidence 0.08 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.06 Pain Relevance 0.07

It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.

Localization (cleavage) of ribose polymerase in poly associated with cancer and apoptosis

13) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.10 Pain Relevance 0.06

-induced cleavage of poly ADP-ribose polymerase protein and apoptosis.

Localization (cleavage) of ADP-ribose polymerase protein in cleavage associated with apoptosis

14) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.96 Pain Relevance 0.61

Prior treatment of natansnin profoundly decreased the increased expression of caspase- 3, PARP cleavage and translocation of cytochrome C from mitochondria to cytosol indicating that natansnin decreases the apoptosis in hepatocytes.

Localization (translocation) of PARP in hepatocytes associated with apoptosis

15) Confidence 0.02 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.73 Pain Relevance 0.03

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