INT15511

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Context Info
Confidence 0.76
First Reported 1989
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 84
Total Number 84
Disease Relevance 63.30
Pain Relevance 24.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
neuronal 5
DRG 5
macrophages 4
neurons 4
nerve 3
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 72 100.00 Very High Very High Very High
Intracerebroventricular 11 99.98 Very High Very High Very High
Arthritis 339 99.96 Very High Very High Very High
Inflammation 1028 99.92 Very High Very High Very High
dorsal root ganglion 696 99.84 Very High Very High Very High
Dorsal horn 213 99.84 Very High Very High Very High
allodynia 39 99.74 Very High Very High Very High
Hyperalgesia 346 99.52 Very High Very High Very High
Pain 205 99.24 Very High Very High Very High
Dorsal horn neuron 26 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 221 100.00 Very High Very High Very High
Cancer 218 100.00 Very High Very High Very High
Nociception 158 100.00 Very High Very High Very High
Renal Cancer 3 100.00 Very High Very High Very High
Arthritis 407 99.96 Very High Very High Very High
INFLAMMATION 1071 99.92 Very High Very High Very High
Apoptosis 495 99.92 Very High Very High Very High
Hepatitis 60 99.92 Very High Very High Very High
Ganglion Cysts 707 99.84 Very High Very High Very High
Toxicity 6 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At all spinal levels, TNFR1 receptor immunoreactivity (TNFR1-ir) was constitutively expressed on cells and afferent fibers within the dorsal root ganglia, afferent fibers of the dorsal root, dorsal root entry zone (REZ) and within lamina I and II of the dorsal horn.
Gene_expression (expressed) of TNFR1 receptor immunoreactivity in dorsal horn associated with dorsal horn
1) Confidence 0.76 Published 2004 Journal Brain Res. Section Abstract Doc Link 15464762 Disease Relevance 1.02 Pain Relevance 0.46
At all spinal levels, TNFR1 receptor immunoreactivity (TNFR1-ir) was constitutively expressed on cells and afferent fibers within the dorsal root ganglia, afferent fibers of the dorsal root, dorsal root entry zone (REZ) and within lamina I and II of the dorsal horn.
Gene_expression (expressed) of TNFR1 in dorsal horn associated with dorsal horn
2) Confidence 0.76 Published 2004 Journal Brain Res. Section Abstract Doc Link 15464762 Disease Relevance 1.01 Pain Relevance 0.45
RT-PCR analysis of microdissected DRG neurons and of the sensory neuronal cell line F11 confirmed the neuronal expression of TNFR1 and excluded that of TNFR2.
Gene_expression (expression) of TNFR1 in F11 associated with dorsal root ganglion
3) Confidence 0.76 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.98 Pain Relevance 0.46
TNFR1 mRNA was expressed in virtually all neurons and in non-neuronal cells with increased levels after LPS in both.
Gene_expression (expressed) of TNFR1 mRNA in neuronal
4) Confidence 0.76 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 1.00 Pain Relevance 0.38
It has been previously shown that TNFR1 expression is upregulated following nerve injury and parallels the display of nociceptive behavior.
Gene_expression (expression) of TNFR1 in nerve associated with nociception and nervous system injury
5) Confidence 0.75 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760128 Disease Relevance 0.85 Pain Relevance 0.36
Prosaptide prevents hyperalgesia and reduces peripheral TNFR1 expression following TNF-alpha nerve injection.
Gene_expression (expression) of TNFR1 in nerve associated with hyperalgesia
6) Confidence 0.75 Published 1998 Journal Neuroreport Section Title Doc Link 9760128 Disease Relevance 0.87 Pain Relevance 0.39
Expression of TNFR1 (P55 receptors) and TNFR2 (P75 receptors) by the masseter muscle and trigeminal ganglion neurons that innervate that muscle was determined by Western blot and immunohistochemistry, respectively.
Gene_expression (Expression) of TNFR1 in neurons associated with ganglion cysts and trigeminal ganglion neurons
7) Confidence 0.74 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19553487 Disease Relevance 0.45 Pain Relevance 0.30
P55 and P75 receptors were expressed by 29 and 62% of masseter nociceptors, respectively.
Gene_expression (expressed) of P55 in nociceptors associated with nociceptor
8) Confidence 0.74 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19553487 Disease Relevance 0.39 Pain Relevance 0.49
These findings are the first to show that biomechanical signals regulate the expression of TNFR2 but not TNFR1 under inflammatory conditions.
Gene_expression (expression) of TNFR1 associated with inflammation
9) Confidence 0.69 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.98 Pain Relevance 0.13
We sought to examine whether cyclic tensile strain (CTS) regulates the gene expression of tumor necrosis factor (TNF)-alpha, its receptors TNFR1 and TNFR2, and inducible nitric oxide synthase (iNOS) under inflammatory conditions, and whether these effects of CTS are sustained.
Gene_expression (expression) of TNFR1 associated with necrosis, inflammation, cancer and sprains and strains
10) Confidence 0.69 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.97 Pain Relevance 0.14
TNFR1 was constitutively expressed but not regulated by IL-1beta or CTS.
Neg (not) Gene_expression (expressed) of TNFR1 associated with sprains and strains
11) Confidence 0.69 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 1.29 Pain Relevance 0.14
Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-alpha-containing neurons overexpress TNFR1.
Gene_expression (overexpress) of TNFR1 in dorsal root ganglia associated with necrosis, nervous system injury, cancer and spinal dorsal horn
12) Confidence 0.69 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.45 Pain Relevance 0.25
during the structural regression of the CL by analysis of TNFR expression, and to determine the role of TNF?
Gene_expression (expression) of TNFR
13) Confidence 0.68 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.23 Pain Relevance 0
Whilst the significance of these findings is not discussed it is possible that it reflects either latent TNFR protein expression or is the result of the homology between the TNFR death domain and the death domain of adapter proteins localized within the cytoplasm.
Gene_expression (expression) of TNFR associated with death
14) Confidence 0.68 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.25 Pain Relevance 0
TNFR mRNA was expressed in the rat CL at all stages examined during pregnancy and post-partum.
Gene_expression (expressed) of TNFR mRNA
15) Confidence 0.68 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.30 Pain Relevance 0
Immunohistochemical staining indicated that TNFR1 and TNFR2 (Figure 1) were present in the rat CL.
Gene_expression (present) of TNFR1
16) Confidence 0.68 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0 Pain Relevance 0
Using RT-PCR and Northern blotting TNFR1 and TNFR2 mRNAs were found to be constitutively expressed and increased after LPS.
Gene_expression (expressed) of TNFR1
17) Confidence 0.66 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 1.01 Pain Relevance 0.39
Therefore, we differentiated the neuronal and non-neuronal sites of TNFalpha, TNFR1, and TNFR2 mRNA synthesis in dorsal root ganglion (DRG) of control rats and evaluated how their expression is altered under systemic challenge with LPS.
Gene_expression (synthesis) of TNFR1 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
18) Confidence 0.66 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.84 Pain Relevance 0.26
The unilateral sciatic and spinal nerve ligation as well as the sciatic nerve transection were used to induce changes in the distribution of TNF-alpha and TNFR1 proteins.
Gene_expression (distribution) of TNFR1 in sciatic nerve associated with eae and sciatic nerve
19) Confidence 0.66 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.37 Pain Relevance 0.18
After induction of CFA arthritis, expression of both TNFR1 and TNFR2 within the DRG tissues was markedly increased.
Gene_expression (expression) of TNFR1 associated with dorsal root ganglion and arthritis
20) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.26 Pain Relevance 0.90

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