INT155113

Context Info Confidence 0.29 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0.08

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1) plasma membrane (NEU1) lysosome (NEU1)

NEU1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 83.52

Disease Link Frequency Relevance Heat Cancer 2 99.88 Breast Cancer 2 89.28 Metastasis 1 84.56 Advanced Or Metastatic Breast Cancer 1 70.60 Immunotherapy Of Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Targeted therapy against human epidermal growth factor receptor 2 (anti-HER-2) is very effective in tumors that overexpress HER-2/neu receptors, but cost largely prevents its use in resource-limited environments.

Positive_regulation (overexpress) of Gene_expression (overexpress) of neu associated with cancer

1) Confidence 0.29 Published 2008 Journal Cancer Section Abstract Doc Link 18837019 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

This test has worked.