INT15514

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 9
Speculated 2
Reported most in Abstract
Documents 275
Total Number 277
Disease Relevance 194.60
Pain Relevance 64.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
erythrocyte 11
plasma 8
coronary artery 8
joint 7
blood 5
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 788 100.00 Very High Very High Very High
Arthritis 487 100.00 Very High Very High Very High
Pain 469 100.00 Very High Very High Very High
Inflammatory marker 310 100.00 Very High Very High Very High
depression 241 100.00 Very High Very High Very High
headache 15 100.00 Very High Very High Very High
Inflammation 2422 99.96 Very High Very High Very High
Adalimumab 78 99.82 Very High Very High Very High
aspirin 61 99.82 Very High Very High Very High
COX-2 inhibitor 30 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3060 100.00 Very High Very High Very High
Rheumatoid Arthritis 810 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 687 100.00 Very High Very High Very High
Coronary Artery Disease 648 100.00 Very High Very High Very High
Arthritis 398 100.00 Very High Very High Very High
Depression 383 100.00 Very High Very High Very High
Pain 364 100.00 Very High Very High Very High
Headache 21 100.00 Very High Very High Very High
Hypergammaglobulinemia 3 100.00 Very High Very High Very High
Weight Loss 163 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a significant improvement of arthritic symptoms including pain and mental symptoms, as well as a decrease in CRP, was observed after the patient was commenced on a combined treatment of psychotropic medication (antidepressant and atypical neuroleptic).
Negative_regulation (decrease) of CRP associated with pain, antidepressant and arthritis
1) Confidence 0.59 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.77 Pain Relevance 0.90
In this case report, the treatment with risperidone failed to show reductions in CRP level and relevant symptoms of arthritis, pain and depression.
Negative_regulation (reductions) of CRP associated with pain, depression and arthritis
2) Confidence 0.59 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.15 Pain Relevance 0.62
Subjective improvement was well correlated with a reduction of CRP by 45% and BASFI by 73%.
Negative_regulation (reduction) of CRP
3) Confidence 0.58 Published 2002 Journal Nucl Med Commun Section Abstract Doc Link 11748439 Disease Relevance 0.73 Pain Relevance 0.67
Tenidap was also associated with an 18% reduction in erythrocyte sedimentation rate (ESR) and a marked, 51%, reduction in serum C-reactive protein (CRP) level, both of which were significantly greater than the changes in the placebo group (p < 0.05).
Negative_regulation (reduction) of CRP in erythrocyte
4) Confidence 0.58 Published 1996 Journal Scand. J. Rheumatol. Section Abstract Doc Link 8996468 Disease Relevance 0.31 Pain Relevance 0.31
Tenidap was also associated with an 18% reduction in erythrocyte sedimentation rate (ESR) and a marked, 51%, reduction in serum C-reactive protein (CRP) level, both of which were significantly greater than the changes in the placebo group (p < 0.05).
Negative_regulation (reduction) of C-reactive protein in erythrocyte
5) Confidence 0.58 Published 1996 Journal Scand. J. Rheumatol. Section Abstract Doc Link 8996468 Disease Relevance 0.31 Pain Relevance 0.31
In all other patients, CRP levels were decreasing rapidly and normal levels were reached by day 8.
Negative_regulation (decreasing) of CRP
6) Confidence 0.58 Published 1995 Journal Neurochirurgie Section Abstract Doc Link 8577354 Disease Relevance 0.86 Pain Relevance 0.15
C-reactive protein (CRP) levels were significantly reduced in the intervention group (P<0.02).
Negative_regulation (reduced) of C-reactive protein
7) Confidence 0.58 Published 2007 Journal Int. J. Impot. Res. Section Abstract Doc Link 17673936 Disease Relevance 0.45 Pain Relevance 0.09
C-reactive protein (CRP) levels were significantly reduced in the intervention group (P<0.02).
Negative_regulation (reduced) of CRP
8) Confidence 0.58 Published 2007 Journal Int. J. Impot. Res. Section Abstract Doc Link 17673936 Disease Relevance 0.45 Pain Relevance 0.09
Reduction of C-reactive protein by a single 80 mg of simvastatin in patients with unstable angina.
Negative_regulation (Reduction) of C-reactive protein associated with angina
9) Confidence 0.58 Published 2007 Journal Clin. Chim. Acta Section Title Doc Link 16999946 Disease Relevance 0.42 Pain Relevance 0.41
There was a small, but non-significant decrease of CRP levels upon treatment.
Negative_regulation (decrease) of CRP
10) Confidence 0.58 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11472751 Disease Relevance 0.94 Pain Relevance 0.09
In the control group CRP concentration decreased less and not significantly (from 16.1 +/- 7.3 to 13.2 +/- 6.8 mg/l; p = 0.18).
Negative_regulation (decreased) of CRP
11) Confidence 0.58 Published 2007 Journal Klin Med (Mosk) Section Abstract Doc Link 18219956 Disease Relevance 1.24 Pain Relevance 0.13
Most patients in both groups displayed a decrease in CRP level by the fourteenth day of the disease.
Negative_regulation (decrease) of CRP associated with disease
12) Confidence 0.58 Published 2007 Journal Klin Med (Mosk) Section Abstract Doc Link 18219956 Disease Relevance 1.30 Pain Relevance 0.21
HYPOTHESIS: The study was undertaken to investigate whether a rapid LDL cholesterol and CRP reduction can be achieved by 2-week simvastatin therapy using a common lipid-lowering protocol in patients with hypercholesterolemia.
Negative_regulation (reduction) of CRP
13) Confidence 0.57 Published 2003 Journal Clin Cardiol Section Body Doc Link 14579918 Disease Relevance 0.10 Pain Relevance 0
However, CRP levels have been shown to decrease in patients who respond to disease modifying antirheumatic drugs.
Negative_regulation (decrease) of CRP associated with disease
14) Confidence 0.55 Published 1994 Journal J Rheumatol Suppl Section Abstract Doc Link 7529838 Disease Relevance 0.89 Pain Relevance 0.21
In patients with acute coronary syndrome early use of atorvastatin was associated with rapid decrease of C-reactive protein level.
Negative_regulation (decrease) of C-reactive protein associated with acute coronary syndrome
15) Confidence 0.55 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16369062 Disease Relevance 0.36 Pain Relevance 0.10
With regard to inflammatory markers, 5 studies observed a reduction in ESR (mean change -3.9 mm/hour) and 3 observed a CRP level reduction (mean change -2.9 mg/dl); only 1 study showed a significant difference for both ESR and CRP.
Negative_regulation (reduction) of CRP
16) Confidence 0.54 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18759255 Disease Relevance 0 Pain Relevance 0
Recently, the Val-MARC (Valsartan-Managing blood pressure Aggressively and evaluating Reductions in hsCRP) study, addressed the issue of whether BP reduction per se lowers CRP levels, or whether selective antagonism of angiotensin type 1 receptors may have independent effects to reduce CRP levels (Ridker et al 2006).
Negative_regulation (reduce) of CRP in blood
17) Confidence 0.54 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.73 Pain Relevance 0.06
In contrast the combination therapy did not reduce CRP levels.
Neg (not) Negative_regulation (reduce) of CRP
18) Confidence 0.54 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.39 Pain Relevance 0
Several therapeutic approaches have been shown to reduce CRP in patients at high cardiovascular risk.
Negative_regulation (reduce) of CRP
19) Confidence 0.54 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.29 Pain Relevance 0.18
The following laboratory and clinical parameters also significantly reduced: ESR (p < 0.0001), CRP (p < 0.02), VAS (p < 0.001), number of total swollen joints (p < 0.001), number of total painful joints (p < 0.01), HAQ scores (p < 0.05) and DAS 28 (p < 0.0001).
Negative_regulation (reduced) of CRP in joints associated with pain and visual analogue scale
20) Confidence 0.54 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17952483 Disease Relevance 0.78 Pain Relevance 0.72

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