INT15515

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2011
Negated 19
Speculated 15
Reported most in Abstract
Documents 700
Total Number 715
Disease Relevance 604.24
Pain Relevance 150.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plasma 44
erythrocyte 25
WBC 20
liver 17
blood 17
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4320 100.00 Very High Very High Very High
Angina 1129 100.00 Very High Very High Very High
Inflammatory marker 515 100.00 Very High Very High Very High
antagonist 148 100.00 Very High Very High Very High
Inflammatory mediators 107 100.00 Very High Very High Very High
Catecholamine 42 100.00 Very High Very High Very High
Inflammatory stimuli 25 100.00 Very High Very High Very High
Pain 596 99.96 Very High Very High Very High
Inflammatory response 474 99.92 Very High Very High Very High
cytokine 882 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5099 100.00 Very High Very High Very High
Disease 2903 100.00 Very High Very High Very High
Coronary Artery Disease 2019 100.00 Very High Very High Very High
Cv General 3 Under Development 1030 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1017 100.00 Very High Very High Very High
Mycobacterial Infection 889 100.00 Very High Very High Very High
Hypertension 878 100.00 Very High Very High Very High
Obesity 811 100.00 Very High Very High Very High
Nicotine Addiction 572 100.00 Very High Very High Very High
Calcification 571 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case report, we describe a patient with chronic psoriatic arthritis that cause impairing pain, increased C-reactive protein levels (CRP) and depressive symptoms.
Positive_regulation (increased) of CRP associated with seronegative spondarthritis, pain, depression and arthritis
1) Confidence 0.70 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.68 Pain Relevance 0.84
In this case report, we describe a patient with chronic psoriatic arthritis that cause impairing pain, increased C-reactive protein levels (CRP) and depressive symptoms.
Positive_regulation (increased) of C-reactive protein associated with seronegative spondarthritis, pain, depression and arthritis
2) Confidence 0.70 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.62 Pain Relevance 0.82
Factors found to be predictive of early hospital death (4.5%) were aneurysm size (> 5 cm), ischaemic heart disease, chronic obstructive pulmonary disease (COPD), preoperatively elevated C-reactive protein (CRP) and a history of aneurysm-related pain preoperatively.
Positive_regulation (elevated) of CRP in heart associated with pain, pulmonary disease, coronary artery disease, aneurism and death
3) Confidence 0.69 Published 1996 Journal Ann Chir Gynaecol Section Abstract Doc Link 8950446 Disease Relevance 1.12 Pain Relevance 0.31
Factors found to be predictive of early hospital death (4.5%) were aneurysm size (> 5 cm), ischaemic heart disease, chronic obstructive pulmonary disease (COPD), preoperatively elevated C-reactive protein (CRP) and a history of aneurysm-related pain preoperatively.
Positive_regulation (elevated) of C-reactive protein in heart associated with pain, pulmonary disease, coronary artery disease, aneurism and death
4) Confidence 0.69 Published 1996 Journal Ann Chir Gynaecol Section Abstract Doc Link 8950446 Disease Relevance 1.12 Pain Relevance 0.31
Patients had a blood culture taken (8 positive), as well as a hematological (leukocytosis 75%) and biochemical screen, C-reactive protein (CRP) (increased in 57 of 66 [86%]) and urinary tract ultrasonography.
Positive_regulation (increased) of CRP in blood associated with leukocytosis
5) Confidence 0.69 Published 1996 Journal Clin. Nephrol. Section Abstract Doc Link 8869786 Disease Relevance 0.82 Pain Relevance 0.17
CRP levels were not increased among migraine sufferers compared with non-migraineurs.
Neg (not) Positive_regulation (increased) of CRP associated with migraine
6) Confidence 0.69 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19438929 Disease Relevance 1.13 Pain Relevance 0.46
In patients who respond to medical treatment for unstable angina, CRP elevation may be a better parameter than the stress test in identifying the presence of persistent plaque instability.
Positive_regulation (elevation) of CRP in plaque associated with stress and angina
7) Confidence 0.69 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11377346 Disease Relevance 1.12 Pain Relevance 0.36
The case report of a 60-year-old female is presented who had severe fatigue, neck pain, occasionally raised temperature and steadily increasing CRP levels.
Positive_regulation (increasing) of CRP in neck associated with pain, neck pain and fatigue
8) Confidence 0.69 Published 2008 Journal Klin. Mikrobiol. Infekc. Lek. Section Abstract Doc Link 18688772 Disease Relevance 0.85 Pain Relevance 0.31
In smokers and people with metabolic syndrome, hsCRP levels are elevated; in elderly people, there seems to be a relationship between hsCRP and CVEs and mortality.
Positive_regulation (elevated) of hsCRP associated with nicotine addiction and metabolic syndrome
9) Confidence 0.69 Published 2001 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 11993695 Disease Relevance 1.04 Pain Relevance 0.15
During the periods of fever, an inflammatory syndrome with hyperleucocytosis and a marked increase in C-reactive protein (CRP) levels and sedimentation rate is observed.
Positive_regulation (increase) of CRP associated with inflammation, syndrome and fever
10) Confidence 0.69 Published 2000 Journal Arch Pediatr Section Abstract Doc Link 10941483 Disease Relevance 1.85 Pain Relevance 0.26
During the periods of fever, an inflammatory syndrome with hyperleucocytosis and a marked increase in C-reactive protein (CRP) levels and sedimentation rate is observed.
Positive_regulation (increase) of C-reactive protein associated with inflammation, syndrome and fever
11) Confidence 0.69 Published 2000 Journal Arch Pediatr Section Abstract Doc Link 10941483 Disease Relevance 1.85 Pain Relevance 0.26
Patients had a blood culture taken (8 positive), as well as a hematological (leukocytosis 75%) and biochemical screen, C-reactive protein (CRP) (increased in 57 of 66 [86%]) and urinary tract ultrasonography.
Positive_regulation (increased) of C-reactive protein in blood associated with leukocytosis
12) Confidence 0.69 Published 1996 Journal Clin. Nephrol. Section Abstract Doc Link 8869786 Disease Relevance 0.83 Pain Relevance 0.17
C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR) were elevated in 39 and 38 patients, respectively.
Positive_regulation (elevated) of CRP in erythrocyte
13) Confidence 0.69 Published 1998 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 9730301 Disease Relevance 0.84 Pain Relevance 0.13
Elevation of CRP differentiated stress tests negative patients with increased risk of major events during follow-up.
Positive_regulation (Elevation) of CRP associated with stress
14) Confidence 0.69 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11377346 Disease Relevance 1.08 Pain Relevance 0.36
Laboratory examination showed elevated C-reactive protein (CRP), thrombocytopenia, nephrotic syndrome and renal dysfunction.
Positive_regulation (elevated) of C-reactive protein associated with renal disease and thrombocytopenia
15) Confidence 0.69 Published 2003 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 12757984 Disease Relevance 1.05 Pain Relevance 0.10
On separate multiple regression analyses, including the most important clinical and laboratory variables, SD of all RR intervals and very low-frequency amplitude were the most significant predictors of increasing CRP levels (p<0.001 for the 2 comparisons).
Positive_regulation (increasing) of CRP
16) Confidence 0.69 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16765117 Disease Relevance 0.64 Pain Relevance 0.62
Laboratory examination showed elevated C-reactive protein (CRP), thrombocytopenia, nephrotic syndrome and renal dysfunction.
Positive_regulation (elevated) of CRP associated with renal disease and thrombocytopenia
17) Confidence 0.69 Published 2003 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 12757984 Disease Relevance 1.05 Pain Relevance 0.10
CRP was elevated (> 1.5 mg/dl) in 40 patients (28.7%).
Positive_regulation (elevated) of CRP
18) Confidence 0.69 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11377346 Disease Relevance 1.04 Pain Relevance 0.32
C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR) were elevated in 39 and 38 patients, respectively.
Positive_regulation (elevated) of C-reactive protein in erythrocyte
19) Confidence 0.69 Published 1998 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 9730301 Disease Relevance 0.84 Pain Relevance 0.13
Blood inflammatory markers revealed normal white cell counts but an elevated C-reactive protein (CRP) of 342 mg/l.
Positive_regulation (elevated) of C-reactive protein in Blood associated with inflammatory marker
20) Confidence 0.69 Published 2008 Journal Cases J Section Body Doc Link PMC2553056 Disease Relevance 1.17 Pain Relevance 0.14

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