INT155150

Context Info Confidence 0.26 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.21 Pain Relevance 0.86

nucleus (Spic) DNA binding (Spic)

Anatomy Link Frequency DRG 2 neural 1 Spic (Mus musculus)

Pain Link Frequency Relevance Heat postherpetic neuralgia 10 100.00 dorsal root ganglion 6 100.00 Pain 2 97.60 Intractable pain 2 92.12 Inflammation 6 82.16 cytokine 12 16.80 cINOD 5 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Post Operative Pain 10 100.00 Ganglion Cysts 6 100.00 Pain 2 97.60 Intractable Pain 2 92.12 INFLAMMATION 7 82.16 Poisoning 4 5.00 Hypertension 3 5.00 Helminth Infection 2 5.00 Alopecia 2 5.00 Congenital Anomalies 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSIONS: PRF lesioning of DRG showed significant pain relief compared with the conventional treatments in patients with intractable PHN.

Gene_expression (lesioning) of PRF in DRG

1) Confidence 0.26 Published 2008 Journal Acta Anaesthesiol Scand Section Body Doc Link 18840116 Disease Relevance 0.13 Pain Relevance 0

We assessed the efficacy of PRF lesioning of DRG for PHN via an open, nonrandomized study.

Gene_expression (lesioning) of PRF in DRG associated with dorsal root ganglion and postherpetic neuralgia

2) Confidence 0.26 Published 2008 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 18840116 Disease Relevance 0.94 Pain Relevance 0.79

Using the data from the whole pheromone study (618% labeling above background) and the data from the two present studies, we find that PRF and PMF together (330% + 124% = 454% labeling above background) produce neural labeling that is 73.5% of that produced by whole pheromone (454% / 618% = 73.5%).

Gene_expression (produce) of PRF in neural

3) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0

When expressed as a percentage of control numbers, whole pheromone (containing both PRF and PMF) produced labeling 618% above control levels while PRF produced 330% labeling and PMF produced 124% labeling above the respective control group levels.

Gene_expression (produced) of PRF

4) Confidence 0.13 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0

As our sample was unselected and PRFs are widely consumed during pregnancy, the larger number of patients in the 75th percentile of PRF intake expresses the high PRF consumption pattern in our population.

Gene_expression (expresses) of PRF

5) Confidence 0.09 Published 2010 Journal J Perinatol Section Body Doc Link PMC2834346 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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