INT155153

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.42
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a1) cytoplasm (S100a1)
Anatomy Link Frequency
axillary 1
muscle 1
bridge 1
pore 1
nucleus 1
S100a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 631 98.72 Very High Very High Very High
imagery 16 98.40 Very High Very High Very High
Arthritis 22 96.56 Very High Very High Very High
rheumatoid arthritis 11 95.32 Very High Very High Very High
antagonist 22 93.96 High High
Pain 36 85.56 High High
cytokine 126 71.04 Quite High
chemokine 1 66.24 Quite High
qutenza 27 34.56 Quite Low
methotrexate 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Juvenile Xanthogranuloma 7 99.68 Very High Very High Very High
Inflammatory Bowel Disease 11 99.28 Very High Very High Very High
Papular Skin Disease 1 98.98 Very High Very High Very High
Targeted Disruption 63 98.86 Very High Very High Very High
Apoptosis 155 98.80 Very High Very High Very High
INFLAMMATION 664 98.28 Very High Very High Very High
Autoimmune Disease 11 97.72 Very High Very High Very High
Juvenile Chronic Polyarthritis 11 96.56 Very High Very High Very High
Arthritis 11 96.36 Very High Very High Very High
Langerhans-cell Histiocytosis 6 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Representing one of the largest subfamilies of the EF-hand calcium-binding proteins with at least 19 different members [10], S100 proteins interact with other proteins to modulate a variety of biologic functions and are thus related to various diseases, many of which involve inflammation, innate immunity, tissue damage, and wound healing [11,12].
S100 Binding (interact) of associated with inflammation, wound healing and disease
1) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.72 Pain Relevance 0.26
By analogy, calmodulin-like mouth of the TRPV1 pore may react just like that described to other EF-hand structures [31] such as the S-100 Ca2+-binding proteins and “Excalibur”.
S-100 Binding (binding) of in pore
2) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0 Pain Relevance 0.09
S100A1 binds to both the tetramerization and negative regulatory domains of p53 [104].
S100A1 Binding (binds) of
3) Confidence 0.21 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.10 Pain Relevance 0.04
There is still some debate if S100A1 binds to RAGE, although recent work with PET Imaging of Fluorine-18 labeled S100A1 administered to mice indicates that it co-localizes with RAGE [117].
S100A1 Binding (binds) of associated with imagery
4) Confidence 0.21 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.15 Pain Relevance 0.05
Some S100 proteins also bind Zn++ or Cu++ with high affinity, and this might affect their ability to bind Ca++ [101].
S100 Binding (bind) of
5) Confidence 0.21 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.16 Pain Relevance 0
This change in conformation allows an S100 dimer to bind two target proteins, and essentially form a bridge between as a heterotetramer [102].
S100 Binding (bind) of in bridge
6) Confidence 0.18 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.13 Pain Relevance 0
In order to determine the source of TSCs in the present experiments in adults, we performed MG muscle transplants between wild-type mice and transgenic mice that express EGFP under the direction of the human S100 calcium-binding protein promoter [16].
S100 Binding (binding) of in muscle associated with targeted disruption
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.26 Pain Relevance 0
S100 Proteins are not universal RAGE ligands
S100 Neg (not) Binding (ligands) of
8) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.56 Pain Relevance 0.19
Possible ligands of RAGE: S100A1, S100A8/9
S100A1 Binding (ligands) of
9) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.06 Pain Relevance 0
One area that has not received much attention is the possibility of S100 binding to a soluble RAGE in the cytosol or nucleus (as opposed to extracellular soluble RAGE).


S100 Binding (binding) of in nucleus
10) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.70 Pain Relevance 0.22
Nonetheless, an additional axillary papule was once again consistent with JXG, with negative reaction for S100 and CD1a with no Birbeck granules by electron microscopy.
S100 Neg (negative) Binding (reaction) of in axillary associated with juvenile xanthogranuloma and papular skin disease
11) Confidence 0.16 Published 2008 Journal J. Cutan. Pathol. Section Abstract Doc Link 18840155 Disease Relevance 1.04 Pain Relevance 0.09
S100A5 is also a Zn++ binder, but it binds Ca++ with 20–100 fold greater affinity than other S100 proteins.
S100 Binding (binds) of
12) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0
For example, S100 dimers and higher-order multimers bind several receptors including TLR4, and clustering of RAGE could promote a similarly strong response [47].
S100 Binding (bind) of
13) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.33 Pain Relevance 0.07
Blockade of the S100-RAGE interaction with soluble RAGE in mice reduced colonic inflammation in IL-10-deficient mice, inhibited arthritis development, and suppressed inflammatory cell infiltration [43,33,32,105].
S100 Binding (interaction) of associated with inflammation and arthritis
14) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.22 Pain Relevance 0.33
There are several important questions that need to be addressed when examining proposed S100-RAGE interactions: Does this interaction occur in vivo in addition to in vitro?
S100 Binding (interactions) of
15) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.29

General Comments

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