INT15516

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Context Info
Confidence 0.77
First Reported 1981
Last Reported 2011
Negated 13
Speculated 35
Reported most in Body
Documents 711
Total Number 746
Disease Relevance 615.33
Pain Relevance 173.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plasma 58
liver 28
erythrocyte 24
leukocyte 23
blood 19
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5819 100.00 Very High Very High Very High
rheumatoid arthritis 3026 100.00 Very High Very High Very High
cytokine 1674 100.00 Very High Very High Very High
Arthritis 1340 100.00 Very High Very High Very High
Inflammatory marker 752 100.00 Very High Very High Very High
Pain 711 100.00 Very High Very High Very High
psoriasis 524 100.00 Very High Very High Very High
metalloproteinase 244 100.00 Very High Very High Very High
Catecholamine 29 100.00 Very High Very High Very High
Angina 1060 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7239 100.00 Very High Very High Very High
Disease 4981 100.00 Very High Very High Very High
Rheumatoid Arthritis 3091 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1095 100.00 Very High Very High Very High
Seronegative Spondarthritis 671 100.00 Very High Very High Very High
Cancer 660 100.00 Very High Very High Very High
Pain 617 100.00 Very High Very High Very High
Acute Coronary Syndrome 615 100.00 Very High Very High Very High
Psoriasis 580 100.00 Very High Very High Very High
Calcification 578 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Levels of C-reactive protein and complement 4 fraction in hyperthermia secondary to microsurgical vascular decompression for trigeminal neuralgia].
Gene_expression (Levels) of C-reactive protein associated with trigeminal neuralgia and fever
1) Confidence 0.77 Published 1995 Journal Neurochirurgie Section Title Doc Link 8577354 Disease Relevance 0.77 Pain Relevance 0.19
CONCLUSIONS: Elevated CRP levels were observed in elderly men in a number of chronic diseases, indicating a persistent inflammatory response.
Gene_expression (levels) of CRP
2) Confidence 0.76 Published 2009 Journal Scand J Public Health Section Body Doc Link 19372230 Disease Relevance 0.27 Pain Relevance 0
AIMS: To compare the levels of C-reactive protein (CRP) in a range of chronic disorders such as osteoporosis, asthma, diabetes, chronic bronchitis/emphysema, myocardial infarction, current oral infections, stroke, angina pectoris, hay fever, and fibromyalgia/chronic pain syndrome.
Gene_expression (levels) of C-reactive protein associated with complex regional pain syndromes, angina, stroke, diabetes mellitus, osteoporosis, chronic pain syndrome, bronchitis, fibrositis, infection, asthma, rhinitis, emphysema and myocardial infarction
3) Confidence 0.76 Published 2009 Journal Scand J Public Health Section Abstract Doc Link 19372230 Disease Relevance 1.14 Pain Relevance 0.23
AIMS: To compare the levels of C-reactive protein (CRP) in a range of chronic disorders such as osteoporosis, asthma, diabetes, chronic bronchitis/emphysema, myocardial infarction, current oral infections, stroke, angina pectoris, hay fever, and fibromyalgia/chronic pain syndrome.
Gene_expression (levels) of CRP associated with complex regional pain syndromes, angina, stroke, diabetes mellitus, osteoporosis, chronic pain syndrome, bronchitis, fibrositis, infection, asthma, rhinitis, emphysema and myocardial infarction
4) Confidence 0.76 Published 2009 Journal Scand J Public Health Section Abstract Doc Link 19372230 Disease Relevance 1.14 Pain Relevance 0.23
A review of their preoperative total leucocyte count (TLC) and CRP levels and percentage of neutrophil count was made.
Gene_expression (levels) of CRP in leucocyte
5) Confidence 0.76 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702981 Disease Relevance 0.55 Pain Relevance 0
In order to correct for the differing normal ranges CRP results were expressed as the quotient of the absolute CRP value divided by the upper limit of normal for the assay.
Gene_expression (expressed) of CRP in upper
6) Confidence 0.74 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018418 Disease Relevance 0.48 Pain Relevance 0.03
Polymorphisms in CRP have been associated with differential CRP concentrations among healthy adults, with some evidence for functional effects on CRP expression.
Gene_expression (expression) of CRP
7) Confidence 0.74 Published 2009 Journal Pharmacogenet. Genomics Section Abstract Doc Link 19077918 Disease Relevance 0.35 Pain Relevance 0.12
Recent findings have documented that CRP is also produced by vascular smooth muscle cells and endothelial cells, and in human atheroma (Yasojima et al 2001; Venugopal et al 2005).
Gene_expression (produced) of CRP in endothelial cells associated with atherosclerosis
8) Confidence 0.72 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.32 Pain Relevance 0.23
CRP is an acute phase protein that is produced by the liver during an inflammatory reaction.
Gene_expression (produced) of CRP in liver associated with inflammation
9) Confidence 0.72 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 1.33 Pain Relevance 0.53
In particular, obesity is strongly associated with CRP concentration (6, 10), because adipose tissue produces proinflammatory cytokines such as interleukin-6 (IL-6), which stimulates the production of CRP (11).
Gene_expression (production) of CRP in adipose tissue associated with obesity and cytokine
10) Confidence 0.71 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721988 Disease Relevance 1.07 Pain Relevance 0.11
In addition, ROS can activate the transcription factor NF-kB, that is ubiquitously expressed and mediates the expression of genes involved in the acute inflammatory response, including the cytokines IL1-IL6 and IL8 [23], which in turn modulate CRP production.
Gene_expression (production) of CRP associated with inflammatory response and cytokine
11) Confidence 0.70 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.59 Pain Relevance 0.20
However, little is known about the association of serum UA and CRP levels with CSX.
Gene_expression (levels) of CRP
12) Confidence 0.69 Published 2009 Journal Acta Cardiol Section Abstract Doc Link 19476113 Disease Relevance 0.68 Pain Relevance 0.20
These findings can be explained by an enhanced production of cytokines, which in turn trigger CRP synthesis, induced by postoperative pain due to the LAST procedure.
Gene_expression (synthesis) of CRP associated with perioperative pain, thoracotomy and cytokine
13) Confidence 0.68 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12227696 Disease Relevance 0.17 Pain Relevance 0.32
Interleukin-6 (IL-6), IL-1, and tumor necrosis factor alpha induce the synthesis of CRP in hepatocytes.
Gene_expression (synthesis) of CRP in hepatocytes associated with necrosis and cancer
14) Confidence 0.68 Published 2002 Journal Curr Oncol Rep Section Abstract Doc Link 11937016 Disease Relevance 1.57 Pain Relevance 0.11
Lastly, her previous treatment with a combination of drugs of similar classes failed to neither produce relevant relief of either mental and/or physical symptoms nor lower her CRP levels.
Gene_expression (levels) of CRP
15) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.70 Pain Relevance 1.04
In contrast, our patient's commencement on quetiapine treatment, while her SSRI medication was maintained, was related to a reduction in her CRP levels and a clinical improvement in all other areas.
Gene_expression (levels) of CRP associated with ssri
16) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.11 Pain Relevance 0.64
This case report is supports the suggestion that joint inflammatory pathways between arthritis and depression as symptoms of arthritis, pain and depression are simultaneously lifted when CRP levels are lowered.
Gene_expression (levels) of CRP in joint associated with pain, depression, inflammation and arthritis
17) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.57 Pain Relevance 1.24
Differences in age at onset of the disease, time since the diagnosis, C-reactive protein (CRP) levels, and hip involvement were statistically significant.
Gene_expression (levels) of C-reactive protein in hip associated with disease
18) Confidence 0.67 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 19685294 Disease Relevance 0.99 Pain Relevance 0.73
Differences in age at onset of the disease, time since the diagnosis, C-reactive protein (CRP) levels, and hip involvement were statistically significant.
Gene_expression (levels) of CRP in hip associated with disease
19) Confidence 0.67 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 19685294 Disease Relevance 0.98 Pain Relevance 0.72
We sought to assess the prognostic value of non-obstructive coronary stenoses and C-reactive protein (CRP) levels in patients with chronic stable angina (CSA).
Gene_expression (levels) of CRP associated with coronary stenosis and angina
20) Confidence 0.67 Published 2009 Journal Atherosclerosis Section Abstract Doc Link 18823889 Disease Relevance 0.54 Pain Relevance 0.10

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