INT155170

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SUCLA2) small molecule metabolic process (SUCLA2) ligase activity (SUCLA2)
SUCLA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 93.68 High High
Pain 1 86.40 High High
adenocard 1 76.72 Quite High
peripheral neuropathy 8 72.40 Quite High
cytokine 1 25.00 Low Low
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Electroencephalography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 1 99.70 Very High Very High Very High
INFLAMMATION 6 93.68 High High
Fever 1 86.80 High High
Pain 1 86.40 High High
Disease 20 85.36 High High
Ulcers 1 84.44 Quite High
Syndrome 6 81.28 Quite High
Liver Failure 1 76.56 Quite High
Epilepsy 1 74.96 Quite High
Ataxia 11 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Negative_regulation (reduction) of Localization (accumulation) of SUCLA2
1) Confidence 0.38 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.66 Pain Relevance 0.07
We also measured its anti-allergic effect by its inhibition of beta-hexosamidase release.
Negative_regulation (inhibition) of Localization (release) of beta-hexosamidase associated with hypersensitivity
2) Confidence 0.00 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

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