INT155194

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.87
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
skin 3
neuronal 2
masseter 1
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 124 100.00 Very High Very High Very High
nMDA receptor 18 100.00 Very High Very High Very High
cerebral cortex 1 99.28 Very High Very High Very High
Glutamate 20 75.00 Quite High
Lasting pain 18 71.28 Quite High
Hyperalgesia 154 55.24 Quite High
nMDA receptor antagonist 4 49.84 Quite Low
cytokine 52 45.72 Quite Low
anesthesia 11 25.00 Low Low
Pain 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermatitis 4 100.00 Very High Very High Very High
INFLAMMATION 136 87.84 High High
Cretinism 2 87.28 High High
Injury 24 86.80 High High
Intellectual Impairment 1 84.16 Quite High
Pain 42 70.40 Quite High
Thyroid Disease 2 56.48 Quite High
Hyperalgesia 154 55.24 Quite High
Neuropathic Pain 24 5.00 Very Low Very Low Very Low
Nociception 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Neg (without) Regulation (altering) of Phosphorylation (phosphorylation) of GFAP in neuronal associated with cerebral cortex
1) Confidence 0.24 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.16
Effects of masseter and skin inflammation on NMDA receptor phosphorylation and GFAP protein levels
Regulation (Effects) of Phosphorylation (phosphorylation) of GFAP in skin associated with inflammation, nmda receptor and dermatitis
2) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.78 Pain Relevance 0.56
Effects of masseter and skin inflammation on NMDA receptor phosphorylation and GFAP protein levels
Regulation (Effects) of in masseter Phosphorylation (phosphorylation) of GFAP in skin associated with inflammation, nmda receptor and dermatitis
3) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.78 Pain Relevance 0.56

General Comments

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