INT155196

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.15

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peptidase activity (CFI) extracellular space (CFI) extracellular region (CFI)
Anatomy Link Frequency
neuronal 1
CFI (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 1 97.36 Very High Very High Very High
Glutamate 4 75.00 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cretinism 2 86.76 High High
Intellectual Impairment 1 83.64 Quite High
Thyroid Disease 2 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Phosphorylation (phosphorylation) of IF in neuronal associated with cerebral cortex
1) Confidence 0.80 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

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