INT155200

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (VCP) endoplasmic reticulum (VCP) cytoplasm (VCP)
cytosol (VCP) lipid binding (VCP) cell death (VCP)
Anatomy Link Frequency
reticulum 1
VCP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 59.12 Quite High
Disease Link Frequency Relevance Heat
Frontotemporal Dementia 4 97.34 Very High Very High Very High
Disease 3 96.32 Very High Very High Very High
Muscle Disease 3 95.60 Very High Very High Very High
Muscle Weakness 1 84.08 Quite High
Death 1 75.04 Quite High
Pagets Disease 2 75.00 Quite High
Myocardial Infarction 1 71.68 Quite High
Pain 1 59.12 Quite High
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inclusion body myopathy (IBM) associated with Paget disease of the bone (PDB) and frontotemporal dementia (FTD) (now called IBMPFD), is a progressive autosomal dominant disorder that was recently identified as being caused by mutations in the VCP (p97 or CDC48) gene which plays a key role in the ubiquitin-proteasome dependent degradation of cytosolic proteins and in the retro translocation of misfolded proteins from the endoplasmic reticulum into the cytoplasm.
Protein_catabolism (degradation) of VCP in reticulum associated with frontotemporal dementia, muscle disease and disease
1) Confidence 0.70 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18845250 Disease Relevance 1.18 Pain Relevance 0.06

General Comments

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