INT155201

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 8.25
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (VCP) endoplasmic reticulum (VCP) cytoplasm (VCP)
cytosol (VCP) lipid binding (VCP) cell death (VCP)
Anatomy Link Frequency
muscle 3
brain 1
heart 1
VCP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 85.04 High High
Hippocampus 24 53.68 Quite High
Neurotransmitter 6 14.44 Low Low
Eae 30 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 570 100.00 Very High Very High Very High
Disease 171 100.00 Very High Very High Very High
Alzheimer's Dementia 3 99.20 Very High Very High Very High
Neurodegenerative Disease 3 97.44 Very High Very High Very High
Muscle Weakness 105 96.60 Very High Very High Very High
Apoptosis 144 90.12 High High
Embryonic Lethality 6 89.68 High High
Frontotemporal Dementia 60 87.20 High High
Pain 9 85.04 High High
Pagets Disease 6 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, Custer et al. have generated transgenic mice expressing VCP/p97 with the R155H and A232E mutations shown to develop pathology of the muscle, bone, and brain exhitibing similar characteristics seen in humans with IBMPFD [32].
Gene_expression (expressing) of p97 in muscle associated with targeted disruption
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.87 Pain Relevance 0
The VCPR155H/+ allele in the knock-in mouse model that we have created expresses the mutant allele at physiological levels as seen in the patients and thus overcomes the problems of over expression.
Gene_expression (expresses) of VCP associated with targeted disruption
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.98 Pain Relevance 0
Generation of the VCPR155H/+ knock-in mouse model for IBMPFD
Gene_expression (Generation) of VCP associated with targeted disruption
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.64 Pain Relevance 0.03
Inclusions seen in the muscle, brain and heart in VCP disease contain ubiquitin, beta amyloid and TDP-43, also seen in other neurodegenerative disorders thus implicating common pathways in their pathogenesis.
Gene_expression (disease) of VCP in brain associated with alzheimer's dementia, neurodegenerative disease and disease
4) Confidence 0.54 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18845250 Disease Relevance 1.37 Pain Relevance 0.09
Inclusions seen in the muscle, brain and heart in VCP disease contain ubiquitin, beta amyloid and TDP-43, also seen in other neurodegenerative disorders thus implicating common pathways in their pathogenesis.
Gene_expression (disease) of VCP in muscle associated with alzheimer's dementia, neurodegenerative disease and disease
5) Confidence 0.18 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18845250 Disease Relevance 1.37 Pain Relevance 0.09
Inclusions seen in the muscle, brain and heart in VCP disease contain ubiquitin, beta amyloid and TDP-43, also seen in other neurodegenerative disorders thus implicating common pathways in their pathogenesis.
Gene_expression (disease) of VCP in heart associated with alzheimer's dementia, neurodegenerative disease and disease
6) Confidence 0.18 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18845250 Disease Relevance 1.37 Pain Relevance 0.09
On the other hand, transgenic mice over-expressing the most common human IBMPFD mutation, R155H, under the regulation of a muscle creatine kinase promoter demonstrated progressive muscle weakness in a dose-dependent manner starting at 6 months of age.
Gene_expression (expressing) of IBMPFD in muscle associated with targeted disruption and muscle weakness
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.45 Pain Relevance 0
Most of these mutated residues causing IBMPFD are three-dimensionally located in close proximity and potentially interact with each other [26].
Gene_expression (causing) of IBMPFD
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.56 Pain Relevance 0
Generation of the VCPR155H/+ knock-in mouse model for IBMPFD
Gene_expression (Generation) of IBMPFD associated with targeted disruption
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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