INT155218

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 13.93
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
Anatomy Link Frequency
plasma 1
mouth 1
bile 1
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 12 100.00 Very High Very High Very High
adenocard 4 99.84 Very High Very High Very High
Bile 14 98.60 Very High Very High Very High
alcohol 39 98.36 Very High Very High Very High
abdominal pain 9 95.12 Very High Very High Very High
spinal inflammation 25 93.44 High High
Inflammation 22 92.08 High High
Cancer pain 1 91.36 High High
rheumatoid arthritis 51 89.72 High High
fluoxetine 7 89.04 High High
Disease Link Frequency Relevance Heat
Lactic Acidosis 27 99.96 Very High Very High Very High
Pharyngitis 9 99.92 Very High Very High Very High
Hypersensitivity 144 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 586 99.46 Very High Very High Very High
Cough 9 99.12 Very High Very High Very High
Dyspnea 9 98.84 Very High Very High Very High
Lymphadenopathy 9 98.80 Very High Very High Very High
Disease 197 98.24 Very High Very High Very High
Gastroenteritis 9 98.00 Very High Very High Very High
Autoimmune Disease 53 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because many drug-drug interactions may occur at the level of drug transporting proteins, we studied interactions of diclofenac with apical ATP-binding cassette (ABC) multidrug efflux transporters.
ABC Binding (interactions) of associated with diclofenac
1) Confidence 0.35 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 18845662 Disease Relevance 0.52 Pain Relevance 0.73
Physical findings associated with the ABC HSR in some patients include lymphadenopathy, mucous membrane lesions (conjunctivitis and mouth ulcerations), and rash.
ABC Binding (associated) of in mouth associated with exanthema, conjunctivitis and lymphadenopathy
2) Confidence 0.21 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.97 Pain Relevance 0
There have been concerns about possible pharmacokinetic interaction between ABC and ethanol, as both are metabolized by alcohol dehydrogenase.
ABC Binding (interaction) of associated with alcohol
3) Confidence 0.18 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.41 Pain Relevance 0.21
At one center, 15 HIV-positive patients who had symptoms of ABC HSR were compared with 30 HIV-positive patients who had symptoms of influenza.11 Gastrointestinal symptoms occurred in 60% of patients with ABC HSR versus 6% of patients with influenza.
ABC Binding (symptoms) of associated with influenza virus infection and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 2.25 Pain Relevance 0.09
ABC HSR can be overlooked, as these symptoms may mimic various other disease conditions such as influenza, pneumonia, gastroenteritis.
ABC Binding (overlooked) of associated with influenza virus infection, gastroenteritis, pneumonia and disease
5) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 2.17 Pain Relevance 0.10
A study of 145 patients who interrupted ABC treatment showed 1 case of hypersensitivity but no statistical difference in incidence between the study patients who did not interrupt ABC.17
ABC Neg (not) Binding (interrupt) of associated with hypersensitivity
6) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.97 Pain Relevance 0
Lactic acidosis results from the inhibition of mitochondrial DNA synthesis by the nucleoside analogs, resulting in anaerobic glycolysis and intracelluar accumulation of lactate. 3TC has greater affinity for mitochondrial DNA than does ABC.56,57 In vitro data have shown that neither 3TC nor ABC is associated with hepatic cytotoxicity or depletion of mitochondrial DNA.58 Furthermore, in a cohort study evaluating the risk factors for hyperlactatemia and lactic acidosis, ABC/3TC was associated with the lowest relative risk amongst NRTI pairs in the trial.59 The combination of ABC + 3TC also has been shown to have minimal or no effects on in terms of lipoatrophy as well as favorable lipid insulin and other metabolic effects.60–62 Replacing stavudine with abacavir or zidovudine has been shown to improve stavudine-induced lipoatrophy.63

Resistance

ABC Binding (associated) of associated with lactic acidosis and lipodystrophy
7) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.74 Pain Relevance 0
Lactic acidosis results from the inhibition of mitochondrial DNA synthesis by the nucleoside analogs, resulting in anaerobic glycolysis and intracelluar accumulation of lactate. 3TC has greater affinity for mitochondrial DNA than does ABC.56,57 In vitro data have shown that neither 3TC nor ABC is associated with hepatic cytotoxicity or depletion of mitochondrial DNA.58 Furthermore, in a cohort study evaluating the risk factors for hyperlactatemia and lactic acidosis, ABC/3TC was associated with the lowest relative risk amongst NRTI pairs in the trial.59 The combination of ABC + 3TC also has been shown to have minimal or no effects on in terms of lipoatrophy as well as favorable lipid insulin and other metabolic effects.60–62 Replacing stavudine with abacavir or zidovudine has been shown to improve stavudine-induced lipoatrophy.63

Resistance

ABC Binding (associated) of associated with lactic acidosis and lipodystrophy
8) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.82 Pain Relevance 0
Patients were randomly assigned to f-AMV or NFV (2:1) for a minimum of 48 weeks, with a background of ABC and 3TC.
ABC Binding (background) of
9) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.23 Pain Relevance 0
The most important adverse event associated with ABC is the ABC hypersensitivity reaction (ABC HSR).
ABC Binding (associated) of associated with hypersensitivity
10) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 1.34 Pain Relevance 0.08
that all ABC cassettes bind and hydrolyze ATP in a similar way and use
ABC Binding (bind) of
11) Confidence 0.13 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0.06 Pain Relevance 0.08
Some of these regions have previously been associated with autoimmunity; for example rs10484565 falls in a gene called TAP2, which encodes a membrane-associated protein that is a member superfamily of ATP-binding cassette (ABC) transporters.
ABC Binding (binding) of associated with autoimmune disease
12) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 1.17 Pain Relevance 0.25
Sequence alignment of the C. perfringens CpABC and ABC
ABC Binding (alignment) of
13) Confidence 0.12 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0.09
Mg-ADP binding core of the ABC subunit and all the structural motifs
ABC Binding (core) of
14) Confidence 0.10 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0
Sequence alignment of the C. perfringens CpABC and ABC
CpABC Binding (alignment) of
15) Confidence 0.10 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0.09
Mg-ADP binding core of the ABC subunit and all the structural motifs
ABC Binding (binding) of
16) Confidence 0.10 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0
structure of CpABC and the Mg-ADP bound Mj0796 (template, PDB
CpABC Binding (bound) of
17) Confidence 0.10 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0
We have recently found interaction between meat intake and polymorphisms in the ATP-binding cassette (ABC) transporter B1 (ABCB1, MDR1) which encodes glycoprotein P involved in reverse transport of carcinogens and other xenobiotic substances [20].
ABC Binding (binding) of
18) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 1.11 Pain Relevance 0.29
Overexpression of the membrane-bound ATP-binding cassette (ABC) transporters on the surfaces of leishmanias is another mechanism of antimonial resistance.
ABC Binding (bound) of
19) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.20 Pain Relevance 0
The intracellular accumulation of miltefocine includes the following steps: binding to plasma membrane, internalization in the parasite cell (two proteins, the miltefosine transporter LdMT and its beta subunit LdRos3, are the most significant), and intracellular targeting and metabolism [48].
miltefosine transporter LdMT Binding (binding) of in plasma
20) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox