INT15529

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 18.55
Pain Relevance 8.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GCG) signal transduction (GCG) extracellular space (GCG)
small molecule metabolic process (GCG) extracellular region (GCG) plasma membrane (GCG)
Anatomy Link Frequency
plasma 8
ileum 2
neuron 2
salivary gland epithelium 2
smooth muscle 1
GCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 275 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Cholecystokinin 9 100.00 Very High Very High Very High
Action potential 24 99.96 Very High Very High Very High
narcan 14 99.54 Very High Very High Very High
tetrodotoxin 32 99.12 Very High Very High Very High
Opioid 17 98.08 Very High Very High Very High
tolerance 18 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Exanthema 4 99.96 Very High Very High Very High
Gastric Motility Disorder 1 99.92 Very High Very High Very High
Metastasis 29 99.76 Very High Very High Very High
Carcinoid 58 99.68 Very High Very High Very High
Obesity 105 99.52 Very High Very High Very High
Weight Loss 40 99.42 Very High Very High Very High
Hypoglycemia 489 99.20 Very High Very High Very High
Diabetes Mellitus 562 99.06 Very High Very High Very High
Overdose 11 97.40 Very High Very High Very High
Impaired Glucose Tolerance 17 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean percentages of glucagon-producing A cells revealed significant increases in the parenchymal (43.0%) and new (55.7%) islets of diabetic patients as compared with the controls (24.3%) and parenchymal (32.2%) islets of nondiabetic patients.
Gene_expression (producing) of glucagon associated with diabetes mellitus
1) Confidence 0.75 Published 1989 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 2562917 Disease Relevance 1.16 Pain Relevance 0.54
Inhibition of dipeptidyl peptidase-4 (DPP-4) increases the concentration of glucagon-like peptide-1, an incretin hormone that stimulates glucose-dependent insulin release, suppresses glucagon production, slows gastric emptying, reduces appetite, and may promote preservation of ?
Gene_expression (production) of glucagon
2) Confidence 0.65 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2584188 Disease Relevance 0.41 Pain Relevance 0
Nine of the 12 pancreatectomized subjects had no detectable 3500-Mr glucagon and the remaining 3 had very low levels.
Neg (no) Gene_expression (detectable) of glucagon
3) Confidence 0.60 Published 1986 Journal Diabetes Section Abstract Doc Link 3525286 Disease Relevance 0.23 Pain Relevance 0.08
The infusion of synthetic human beta-endorphin (4.5 ng/kg/min) produced the following: (1) in normal-weight subjects, no significant change of plasma glucose and pancreatic hormones (insulin, C-peptide, and glucagon), a significant plasma free fatty acids (FFA) increase, and a suppression of glycerol plasma levels; (2) in obese subjects, significant increases of glucose, insulin, C-peptide, and glucagon, a progressive decline of circulating FFA, and no change in glycerol plasma levels.
Neg (no) Gene_expression (produced) of glucagon in plasma associated with obesity
4) Confidence 0.57 Published 1992 Journal Metab. Clin. Exp. Section Abstract Doc Link 1736041 Disease Relevance 0.35 Pain Relevance 0.10
Like anticholinergic agents, glucagon acts directly on the smooth muscle of the gastrointestinal tract to inhibit peristaltic activity [17–19], and should be administered with caution to patients with cardiac disease.
Gene_expression (acts) of glucagon in smooth muscle associated with heart disease
5) Confidence 0.57 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2803136 Disease Relevance 0.70 Pain Relevance 0.10
Since naloxone did not modify plasma levels of insulin and glucagon, an indirect effect of naloxone on adrenal medullary secretion seems to be excluded.
Gene_expression (levels) of glucagon in plasma associated with narcan
6) Confidence 0.55 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6331037 Disease Relevance 0 Pain Relevance 0.50
Our group has recently shown that intravenous alanine is able to partially restore glucagon response to insulin-induced hypoglycemia (13).
Gene_expression (response) of glucagon associated with hypoglycemia
7) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.07 Pain Relevance 0
In addition to the potential effect on recovery of glucagon responses, amino acids might also serve as a substrate alternative to glucose for the brain and therefore limit cognitive dysfunction during hypoglycemia (18), as do lactate (19) and ?
Gene_expression (responses) of glucagon in brain associated with hypoglycemia and cognitive disorder
8) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.10 Pain Relevance 0
Surprisingly, to the best of our knowledge, no study so far has examined whether amino acids given orally may stimulate glucagon response during insulin-induced hypoglycemia in type 1 diabetes.
Gene_expression (response) of glucagon associated with hypoglycemia and diabetes mellitus
9) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.05 Pain Relevance 0
Therefore, our data argue that glucagon-producing ?
Gene_expression (argue) of glucagon
10) Confidence 0.53 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.15
Therefore, our data argue that glucagon-producing ?
Gene_expression (producing) of glucagon
11) Confidence 0.53 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.15
The high rate of beta-endorphin infusion produced pharmacological elevations of opioid plasma levels in both groups; significant (at least P < 0.05) increments in plasma glucose and glucagon levels and no appreciable modification of plasma insulin and C peptide levels in the control group; and a significant (at least P < 0.05) positive response of plasma glucose, insulin, C peptide, and glucagon levels in relatives of obese subjects.
Gene_expression (levels) of glucagon in plasma associated with obesity and opioid
12) Confidence 0.51 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8636293 Disease Relevance 0.71 Pain Relevance 0.33
We also measured fasting plasma glucagon and free insulin levels in patients with pancreatic diabetes and in those with primary diabetes.
Gene_expression (levels) of glucagon in plasma associated with diabetes mellitus
13) Confidence 0.50 Published 1994 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 7825175 Disease Relevance 0.90 Pain Relevance 0.07
The pancreatic islets are composed primarily of the beta cells, which produce insulin, and glucagon-producing alpha cells.
Gene_expression (producing) of glucagon in alpha cells
14) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.15 Pain Relevance 0
cells is that whereas the latter rely exclusively on voltage-gated Ca2+ channels for the upstroke of the action potentials, glucagon-producing ?
Gene_expression (producing) of glucagon associated with action potential
15) Confidence 0.47 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09
The high rate of beta-endorphin infusion produced pharmacological elevations of opioid plasma levels in both groups; significant (at least P < 0.05) increments in plasma glucose and glucagon levels and no appreciable modification of plasma insulin and C peptide levels in the control group; and a significant (at least P < 0.05) positive response of plasma glucose, insulin, C peptide, and glucagon levels in relatives of obese subjects.
Gene_expression (levels) of glucagon in plasma associated with obesity and opioid
16) Confidence 0.46 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8636293 Disease Relevance 0.54 Pain Relevance 0.34
In addition, expression of some neuropeptides such as vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), and substance P in the human salivary gland epithelium during the gestational period was observed, whereas the other polypeptides examined, including glucagon, cholecystokinin (CCK), Leu-enkephalin, and calcitonin were absent.
Spec (observed) Gene_expression (expression) of glucagon in salivary gland epithelium associated with somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
17) Confidence 0.45 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.07 Pain Relevance 0.47
Theophylline did not influence significantly the glucagon-releasing effect of beta-endorphin as well as the reduced glucagon suppression.
Gene_expression (suppression) of glucagon
18) Confidence 0.42 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.07 Pain Relevance 0.06
The influence of beta-endorphin per se on glucose homeostasis was studied in 7 other subjects using the euglycaemic clamp technique in which the endocrine pancreatic function was fixed at its basal level with somatostatin together with replacement of basal insulin and glucagon by the exogenous infusion of these hormones.
Gene_expression (fixed) of glucagon associated with somatostatin
19) Confidence 0.42 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2885994 Disease Relevance 0 Pain Relevance 0.23
The glucagon response was not greater than the sum of the single effects.
Gene_expression (response) of glucagon
20) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2969000 Disease Relevance 0.24 Pain Relevance 0

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