INT15532

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Context Info
Confidence 0.33
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.32
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FFAR1) plasma membrane (FFAR1) signal transducer activity (FFAR1)
Anatomy Link Frequency
plasma 2
fat 1
EPI 1
heart 1
FFAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
narcan 3 92.32 High High
addiction 5 85.04 High High
Opioid 3 80.80 Quite High
Catecholamine 6 50.00 Quite Low
ischemia 22 40.52 Quite Low
Endogenous opioid 1 31.44 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
qutenza 5 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Insulin Resistance 8 99.08 Very High Very High Very High
Obesity 14 98.14 Very High Very High Very High
Diabetes Mellitus 4 97.96 Very High Very High Very High
Targeted Disruption 4 97.24 Very High Very High Very High
Mental Disorders 114 96.88 Very High Very High Very High
Phobia 4 78.60 Quite High
Repression 2 64.76 Quite High
Hypoglycemia 14 56.92 Quite High
Hyperglycemia 20 56.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Philosophers of free will seem to be primarily interested in describing responsibility and freedom in subjects whose free will and responsibility are not affected.
Negative_regulation (Philosophers) of free will
1) Confidence 0.33 Published 2010 Journal Theor Med Bioeth Section Body Doc Link PMC2975916 Disease Relevance 0.96 Pain Relevance 0.04
The infusion of synthetic human beta-endorphin (4.5 ng/kg/min) produced the following: (1) in normal-weight subjects, no significant change of plasma glucose and pancreatic hormones (insulin, C-peptide, and glucagon), a significant plasma free fatty acids (FFA) increase, and a suppression of glycerol plasma levels; (2) in obese subjects, significant increases of glucose, insulin, C-peptide, and glucagon, a progressive decline of circulating FFA, and no change in glycerol plasma levels.
Negative_regulation (decline) of FFA in plasma associated with obesity
2) Confidence 0.08 Published 1992 Journal Metab. Clin. Exp. Section Abstract Doc Link 1736041 Disease Relevance 0.35 Pain Relevance 0.16
Thus, although there was no effect of elevated FFA on PDHa activity at rest in the present study, maybe due to the overnight high-fat diet in both trials, elevated FFA levels have been shown to induce insulin resistance (31,32), and individuals with enhanced circulating FFA levels like type 2 diabetic subjects may experience FFA-mediated insulin resistance at rest (33), potentially in part because of FFA-induced downregulation of PDH (1).
Negative_regulation (downregulation) of FFA-induced in fat associated with diabetes mellitus and insulin resistance
3) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.29 Pain Relevance 0
The downregulation of PDK4 protein content when plasma FFA was reduced by a carbohydrate-rich breakfast in the present study supports previous studies showing that an elevated FFA level is associated with increased PDK4 expression (1,36).
Negative_regulation (reduced) of FFA in plasma
4) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.06 Pain Relevance 0
Data for EPI and NE are presented in Table 3 and data for FFA and glycerol are presented in Table 4.
Negative_regulation (presented) of FFA in EPI
5) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2912905 Disease Relevance 0 Pain Relevance 0
Interestingly, the very few studies examining the effect of insulin therapy on FFA levels also indicate that this therapy may reduce FFA to similar levels.
Spec (may) Negative_regulation (reduce) of FFA
6) Confidence 0.01 Published 2008 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2329728 Disease Relevance 0.24 Pain Relevance 0.04
Recently, Tuunanen et al [67] demonstrated that acute depression of plasma FFA by acipimox, an inhibitor of lipolysis, depressed cardiac work in healthy and diseased humans with additional decreases in cardiac efficiency for heart failing patients.
Negative_regulation (depression) of FFA in heart associated with depression
7) Confidence 0.01 Published 2008 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2329728 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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