INT155347

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 4.16
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 24 99.56 Very High Very High Very High
depression 6 82.48 Quite High
Central nervous system 3 69.08 Quite High
Disease Link Frequency Relevance Heat
Stress 21 99.82 Very High Very High Very High
Targeted Disruption 9 94.20 High High
Depression 9 92.92 High High
Neurodegenerative Disease 15 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CMS procedure inhibited hippocampal protein kinase A (PKA) activity, extracellular signal-regulated kinases (ERK1/2), and calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylation in AQP4(+/+) and AQP4(-/-) mice.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of calcium/calmodulin-dependent protein kinase IV associated with stress
1) Confidence 0.41 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.43 Pain Relevance 0.68
However, fluoxetine restored CMS-induced inhibition of hippocampal CaMKIV phosphorylation in AQP4(+/+) mice but failed in AQP4(-/-) mice.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of CaMKIV associated with stress and fluoxetine
2) Confidence 0.41 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.30 Pain Relevance 0.74
The CMS procedure inhibited hippocampal protein kinase A (PKA) activity, extracellular signal-regulated kinases (ERK1/2), and calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylation in AQP4(+/+) and AQP4(-/-) mice.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of CaMKIV associated with stress
3) Confidence 0.35 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.43 Pain Relevance 0.68

General Comments

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