INT155348

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.92
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
spinal cords 4
brain 2
retina 1
prefrontal 1
temporal lobe 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 15 100.00 Very High Very High Very High
Neuropathic pain 48 99.84 Very High Very High Very High
Inflammation 40 99.50 Very High Very High Very High
antagonist 6 99.30 Very High Very High Very High
gABA 8 99.08 Very High Very High Very High
fluoxetine 16 98.64 Very High Very High Very High
Glutamate 45 94.84 High High
Central nervous system 60 93.24 High High
Spinal cord 101 89.68 High High
Pain 143 88.16 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 84 99.84 Very High Very High Very High
Neuromyelitis Optica 31 99.64 Very High Very High Very High
Convulsion 20 99.64 Very High Very High Very High
INFLAMMATION 50 99.50 Very High Very High Very High
Injury 140 99.36 Very High Very High Very High
Neurodegenerative Disease 25 96.88 Very High Very High Very High
Contusions 7 96.16 Very High Very High Very High
Epilepsy 5 95.44 Very High Very High Very High
Targeted Disruption 51 93.72 High High
Nociception 66 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, another study reported that a significant increase in AQP4 is observed in sclerotic, but not in non-sclerotic, hippocampi obtained from patients with medically intractable temporal lobe epilepsy [39].
Positive_regulation (increase) of AQP4 in temporal lobe associated with epilepsy
1) Confidence 0.63 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.48 Pain Relevance 0.04
Most likely, the function of Dp71 is to stabilize the Kir4.1 and AQP4 channel molecules in specific membrane domains by limiting their lateral diffusion.
Positive_regulation (stabilize) of AQP4 in lateral
2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.20 Pain Relevance 0.07
Interestingly, GFAP and AQP4 are not only increased at the site of injury at 4 weeks after SCI, but also in the spinal segments away from the site of injury; in lumbar (L4/L5 combined) and in cervical (C7/C8 combined) segments in the spinal cords of rats with different level of CNP.
Positive_regulation (increased) of AQP4 in spinal cords associated with injury and neuropathic pain
3) Confidence 0.60 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.37 Pain Relevance 0.77
Interestingly; AQP1 levels were not affected by long-lasting hypertonicity that significantly increased astrocytic AQP4, suggesting that the primary role of AQP1 is not regulating isotonicity in spinal cords.
Positive_regulation (increased) of AQP4 in spinal cords
4) Confidence 0.52 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.17 Pain Relevance 0.82
Binder and co-workers [5] have shown that seizure susceptivity was increased in AQP4 deleted mice suggesting that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity.
Positive_regulation (increased) of AQP4 in brain associated with convulsion
5) Confidence 0.52 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.42 Pain Relevance 0.47
Collectively, these findings suggest that AQP4 is required for the antidepressive action of fluoxetine via regulating adult hippocampal neurogenesis.
Positive_regulation (required) of AQP4 associated with neurodegenerative disease and fluoxetine
6) Confidence 0.50 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 0.92 Pain Relevance 0.66
Requirement of AQP4 for antidepressive efficiency of fluoxetine: implication in adult hippocampal neurogenesis.
Positive_regulation (Requirement) of AQP4 associated with neurodegenerative disease and fluoxetine
7) Confidence 0.50 Published 2009 Journal Neuropsychopharmacology Section Title Doc Link 18923397 Disease Relevance 1.06 Pain Relevance 0.42
Here we show that experimental detachment of mouse retina induces mislocation of the inwardly rectifying potassium channels (Kir4.1) and a downregulation of the water channel protein (AQP4) in Müller cells.
Positive_regulation (induces) of AQP4 in retina associated with potassium channel
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.30 Pain Relevance 0.08
In brain, seizure susceptibility in response to the convulsant (GABA antagonist) pentylenetetrazol was remarkably increased in AQP4 null mice [5].
Positive_regulation (increased) of AQP4 in brain associated with gaba, convulsion and antagonist
9) Confidence 0.43 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.34 Pain Relevance 0.67
A representative western blot shows low AQP4 expression in uninjured samples, and highly increased AQP4 protein levels in the CNP spinal cords, consistent with GFAP expression changes.
Positive_regulation (increased) of AQP4 in spinal cords associated with neuropathic pain
10) Confidence 0.40 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.27 Pain Relevance 0.68
DNA microarray analysis showed significantly increased expression of a number of genes associated with inflammation and astrocytic activation in the spinal cords of rats that developed CNP. mRNA levels of glial fibrilary acidic protein (GFAP) and AQP4 significantly increased in CNP spinal cords of rats.
Positive_regulation (increased) of AQP4 in spinal cords associated with inflammation and neuropathic pain
11) Confidence 0.40 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.16 Pain Relevance 0.64
Observations that encephalitogenic MBP-specific T cells promoted the development of NMO-like lesions upon transfer of AQP4-specific antibodies provided evidence that inflammation initiated by a T cell immune response to a CNS myelin antigen was sufficient for entry of AQP4-specific antibodies, and questions whether the cellular response that initiates CNS inflammation in NMO must necessarily target AQP4.
Positive_regulation (target) of AQP4 in T cell associated with neuromyelitis optica and inflammation
12) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.16 Pain Relevance 0.20
High levels of AQP4 were noted in areas where astrocytes come into direct contact with capillaries, ependymal layer and pia.
Positive_regulation (levels) of AQP4 in astrocytes
13) Confidence 0.22 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.07 Pain Relevance 0
Selective prefrontal NE depletion abolished place conditioning induced by the highly salient stimuli, WCh and IPL, in control groups, as well as by the mildly salient stimuli, MCh and IL, in stressed groups.
Positive_regulation (induced) of WCh in prefrontal
14) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0 Pain Relevance 0

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