INT155349

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.26
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
spinal cords 6
T cell 4
endothelial cells 2
astrocytes 2
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 26 99.68 Very High Very High Very High
fluoxetine 8 98.76 Very High Very High Very High
Inflammation 35 90.96 High High
Spinal cord 64 88.48 High High
Pain 74 71.84 Quite High
Dorsal horn 14 66.56 Quite High
depression 3 62.16 Quite High
Sciatica 3 60.40 Quite High
allodynia 9 51.04 Quite High
Central nervous system 36 48.76 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 44 99.68 Very High Very High Very High
Stress 15 99.50 Very High Very High Very High
Malignant Neoplastic Disease 3 97.18 Very High Very High Very High
Targeted Disruption 37 95.84 Very High Very High Very High
INFLAMMATION 37 90.96 High High
Injury 72 89.28 High High
Cerebral Edema 8 80.96 Quite High
Syndrome 4 78.80 Quite High
Brain Hemorrhage 2 77.04 Quite High
Neurodegenerative Disease 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, CMS procedure significantly increased the hippocampal AQP4 expression, which was reversed by 4-week fluoxetine treatment.
Positive_regulation (increased) of Gene_expression (expression) of AQP4 associated with stress and fluoxetine
1) Confidence 0.70 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.24 Pain Relevance 0.72
A representative western blot shows low AQP4 expression in uninjured samples, and highly increased AQP4 protein levels in the CNP spinal cords, consistent with GFAP expression changes.
Positive_regulation (increased) of Gene_expression (levels) of AQP4 in spinal cords associated with neuropathic pain
2) Confidence 0.60 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.33 Pain Relevance 0.74
Although AQP4 expression is polarized in astrocytes foot processes adjacent to endothelial cells, in the absence of endothelia (e.g. cultured astrocytes and malignant astrocytes) [78, 80, 105] AQP4 redistributes throughout the astrocyte cell membrane, suggesting that endothelial cells signal astrocytes to polarize AQP4 expression in the cell membrane [93].
Positive_regulation (polarize) of Gene_expression (expression) of AQP4 in endothelial cells associated with malignant neoplastic disease
3) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.56 Pain Relevance 0.11
A representative western blot shows low AQP4 expression in uninjured samples, and highly increased AQP4 protein levels in the CNP spinal cords, consistent with GFAP expression changes.
Positive_regulation (low) of Gene_expression (expression) of AQP4 in spinal cords associated with neuropathic pain
4) Confidence 0.43 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.27 Pain Relevance 0.69
A representative western blot shows low AQP4 expression in uninjured samples, and highly increased AQP4 protein levels in the CNP spinal cords, consistent with GFAP expression changes.
Positive_regulation (low) of Gene_expression (expression) of AQP4 in spinal cords associated with neuropathic pain
5) Confidence 0.43 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.29 Pain Relevance 0.69
Interestingly, hyperosmotic treatment of cultured rat astrocytes by mannitol or sorbitol increases the expression of AQP4 and AQP9 mRNAs and proteins, which is suppressed by treatment with the p38 MAPK inhibitor SB203580 [34].
Positive_regulation (increases) of Gene_expression (expression) of AQP4 in astrocytes
6) Confidence 0.41 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
In contrast to AQP4 p21-40-specific T cells, other AQP4 peptide-specific T cell lines proliferated in response to their respective AQP4 determinants, but less efficiently, or not at all, to intact AQP4 (Figure 4C).
Positive_regulation (proliferated) of Neg (not) Spec (determinants) Gene_expression (determinants) of AQP4 in T cell
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.25 Pain Relevance 0
In contrast to AQP4 p21-40-specific T cells, other AQP4 peptide-specific T cell lines proliferated in response to their respective AQP4 determinants, but less efficiently, or not at all, to intact AQP4 (Figure 4C).
Positive_regulation (proliferated) of Neg (not) Spec (determinants) Gene_expression (determinants) of AQP4 in T cell
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.25 Pain Relevance 0
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Positive_regulation (subgroup) of Gene_expression (composed) of AQP4
9) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0

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