INT155352

Context Info Confidence 0.79 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 3.34 Pain Relevance 0.83

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A) nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)

HIF1A (Homo sapiens)

Pain Link Frequency Relevance Heat Nicotine 79 99.44 Central nervous system 1 78.08 cINOD 4 75.44 Potency 1 67.04 antagonist 1 29.12 imagery 14 5.00 cytokine 7 5.00 Inflammation 4 5.00 Chronic pancreatitis 3 5.00 ischemia 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 92 100.00 Apoptosis 20 94.40 Brain Tumor 1 78.76 Reprotox - General 1 6 77.32 Cancer 79 76.84 Carcinoma 1 75.16 INFLAMMATION 5 62.68 Death 7 59.92 Pancreatic Cancer 81 52.96 Metastasis 25 27.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.

Phosphorylation (phosphorylation) of HIF-1alpha

1) Confidence 0.79 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 1.29 Pain Relevance 0.30

In addition, phosphorylation of HIF-1?

Phosphorylation (phosphorylation) of HIF-1

2) Confidence 0.43 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.70 Pain Relevance 0.04

8 M nicotine on the expression of MAPK, phosphorylated MAPK (pMAPK), Akt, phosphorylated Akt (pAkt), and hypoxia inducible factor-1 alpha (HIF-1?)

Phosphorylation (phosphorylated) of hypoxia inducible factor-1 alpha associated with hypoxia and nicotine

3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 1.35 Pain Relevance 0.48

General Comments

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