INT155352

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Context Info
Confidence 0.79
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 79 99.44 Very High Very High Very High
Central nervous system 1 78.08 Quite High
cINOD 4 75.44 Quite High
Potency 1 67.04 Quite High
antagonist 1 29.12 Quite Low
imagery 14 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 92 100.00 Very High Very High Very High
Apoptosis 20 94.40 High High
Brain Tumor 1 78.76 Quite High
Reprotox - General 1 6 77.32 Quite High
Cancer 79 76.84 Quite High
Carcinoma 1 75.16 Quite High
INFLAMMATION 5 62.68 Quite High
Death 7 59.92 Quite High
Pancreatic Cancer 81 52.96 Quite High
Metastasis 25 27.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.
Phosphorylation (phosphorylation) of HIF-1alpha
1) Confidence 0.79 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 1.29 Pain Relevance 0.30
In addition, phosphorylation of HIF-1?
Phosphorylation (phosphorylation) of HIF-1
2) Confidence 0.43 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.70 Pain Relevance 0.04
8 M nicotine on the expression of MAPK, phosphorylated MAPK (pMAPK), Akt, phosphorylated Akt (pAkt), and hypoxia inducible factor-1 alpha (HIF-1?)
Phosphorylation (phosphorylated) of hypoxia inducible factor-1 alpha associated with hypoxia and nicotine
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 1.35 Pain Relevance 0.48

General Comments

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