INT155375

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.55
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc13a3) transmembrane transport (Slc13a3)
Anatomy Link Frequency
trigeminal ganglion 1
Slc13a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.16 Very High Very High Very High
trigeminal ganglion 4 95.82 Very High Very High Very High
tetrodotoxin 8 94.36 High High
Action potential 16 91.24 High High
agonist 12 88.96 High High
Trigeminal ganglion neurons 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 95.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aims of the present study were to investigate whether the activation of the 5-HT receptor subtypes (5-HT(4) and 5-HT(3)) acted significantly on the modification of the tetrodotoxin-resistant sodium current (I(NaR)) in small-sized rat trigeminal ganglion (TG) neurons and whether the inhibition of the transient K(+) current (I(A)) contributed to the excitability in those neurons. 5-HT applications in at concentrations ranging from 0.01-10 microM significantly increased the peak I(NaR).
Positive_regulation (increased) of NaR in trigeminal ganglion associated with ganglion cysts, tetrodotoxin and trigeminal ganglion
1) Confidence 0.32 Published 2008 Journal Neuroscience Section Abstract Doc Link 18926885 Disease Relevance 0.17 Pain Relevance 0.32
The largest effects of 5-HT (1 microM) and RS 67333 (0.1 microM) on the modification of I(NaR) were abolished by pretreatment with ICS 205-930 (a 5-HT(3/4) receptor antagonist, 10 microM), which showed no significant effect on the baseline I(NaR).
Neg (no) Positive_regulation (effect) of NaR associated with antagonist
2) Confidence 0.32 Published 2008 Journal Neuroscience Section Abstract Doc Link 18926885 Disease Relevance 0.14 Pain Relevance 0.41
In addition, neither the additional application of 1 microM 5-HT in the presence of 10 microM forskolin, a stimulator of adenylyl cyclase, nor the opposite applications of 5-HT and forskolin caused the enhancement of increased I(NaR), which indicates the presence of an 'occluding effect.'
Positive_regulation (increased) of NaR
3) Confidence 0.28 Published 2008 Journal Neuroscience Section Abstract Doc Link 18926885 Disease Relevance 0.07 Pain Relevance 0.41
One micromolar 5-HT application caused the greatest increase in the peak I(NaR) amplitude accompanied by a hyperpolarizing shift in the activation curve.
Positive_regulation (increase) of NaR
4) Confidence 0.28 Published 2008 Journal Neuroscience Section Abstract Doc Link 18926885 Disease Relevance 0.16 Pain Relevance 0.32

General Comments

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