INT155391

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
thymus 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 2 50.00 Quite Low
electroacupuncture 2 50.00 Quite Low
Morphine 2 50.00 Quite Low
Kinase C 21 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 52 100.00 Very High Very High Very High
Parkinson's Disease 2 97.32 Very High Very High Very High
Stress 18 91.72 High High
Necrosis 1 47.04 Quite Low
Death 11 31.28 Quite Low
Opiate Addiction 1 27.08 Quite Low
Body Weight 28 5.00 Very Low Very Low Very Low
Hepatotoxicity 14 5.00 Very Low Very Low Very Low
Poisoning 9 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: EA at "Zusanli" (ST 36) can inhibit morphine-induced downregulation of Bcl-2 and upregulation of Fas and FasL expression, which may contribute to its effect in resisting thymus apoptosis in morphine withdrawal rats.


Positive_regulation (induced) of Negative_regulation (downregulation) of Bcl-2 in thymus
1) Confidence 0.22 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
We observed that NaAsO2 induced up-regulation of pro apoptotic (active non-phospho form of Bad, Bax) and down-regulation of anti apoptotic (active non-phospho form of Bcl-2, Bcl-xL) Bcl-2 family proteins both in vivo and in vitro (Fig. 5A, 5B, 5C, 5D).
Positive_regulation (induced) of Negative_regulation (regulation) of Bcl-2 associated with apoptosis
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.92 Pain Relevance 0

General Comments

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