INT155392

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
thymus 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 5 93.20 High High
fluoxetine 4 86.56 High High
antidepressant 3 84.68 Quite High
cINOD 2 82.56 Quite High
depression 1 74.64 Quite High
withdrawal 2 50.00 Quite Low
electroacupuncture 2 50.00 Quite Low
Morphine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 2 99.32 Very High Very High Very High
Death 3 95.64 Very High Very High Very High
Injury 5 93.20 High High
Acute Renal Failure 1 89.64 High High
Toxicity 5 88.64 High High
Cancer 2 84.48 Quite High
INFLAMMATION 1 82.00 Quite High
Disease 1 77.92 Quite High
Cognitive Disorder 1 75.80 Quite High
Depression 1 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: EA at "Zusanli" (ST 36) can inhibit morphine-induced downregulation of Bcl-2 and upregulation of Fas and FasL expression, which may contribute to its effect in resisting thymus apoptosis in morphine withdrawal rats.


Negative_regulation (inhibit) of Negative_regulation (downregulation) of Bcl-2 in thymus
1) Confidence 0.21 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18928115 Disease Relevance 0 Pain Relevance 0
Both compounds prevented the loss of the mitochondrial transmembrane potential, over-expression of Bax, reduction in Bcl-2 level, cytochrome c release, caspase-3 activation, formation of reactive oxygen species and depletion of GSH.
Negative_regulation (prevented) of Negative_regulation (reduction) of Bcl-2
2) Confidence 0.10 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19135049 Disease Relevance 0.90 Pain Relevance 0.57
Indomethacin treatment was associated with the disruption of mitochondrial transmembrane potential, release of cytochrome c, down-regulation of Bcl-2 and Mcl-1, upregulation of Bax, and elevation of caspases activity.
Negative_regulation (down) of Negative_regulation (regulation) of Bcl-2
3) Confidence 0.02 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19250643 Disease Relevance 0.74 Pain Relevance 0.16

General Comments

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