INT1554

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 9.44
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE1)
Anatomy Link Frequency
Muscle 1
RNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 15 99.92 Very High Very High Very High
alcohol 6 97.60 Very High Very High Very High
Paracetamol 1 94.00 High High
cytokine 20 85.16 High High
imagery 1 82.60 Quite High
positron emission tomography 1 80.92 Quite High
peripheral neuropathy 1 77.80 Quite High
Pain 2 64.52 Quite High
Inflammation 15 50.00 Quite Low
fibrosis 7 48.80 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 19 99.92 Very High Very High Very High
Cancer 66 99.48 Very High Very High Very High
Pancreatic Cancer 31 98.68 Very High Very High Very High
Obstructive Jaundice 4 98.16 Very High Very High Very High
Nasopharynx Cancer 145 96.68 Very High Very High Very High
Hepatitis C Virus Infection 72 95.72 Very High Very High Very High
Disease 18 95.00 High High
Skin Cancer 1 94.76 High High
Malignant Neoplastic Disease 7 93.20 High High
Apoptosis 14 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The correlation of increased serum RNase levels with tumor histology and different chromatographic pattern may explain the new enzyme production in cancer patients, and have biological significance in the development of pancreatic cancer.
Positive_regulation (increased) of serum RNase associated with cancer and pancreatic cancer
1) Confidence 0.67 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 215487 Disease Relevance 1.59 Pain Relevance 0.14
Increasing RNAse concentration from 0.35 to 0.7 mM in the formulation did not result in a statistically significant increase in delivery.
Positive_regulation (Increasing) of RNAse
2) Confidence 0.61 Published 2010 Journal J Control Release Section Abstract Doc Link 20423719 Disease Relevance 0 Pain Relevance 0.09
These data suggest that the finding of increased serum RNase is of adjunctive value inthe diagnosis of pancreatic carcinoma and may be particularly helpful in distinguishing it from other causes of biliary obstruction and from chronic pancreatitis.
Positive_regulation (increased) of serum RNase associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.57 Published 1980 Journal Am. J. Surg. Section Abstract Doc Link 7350842 Disease Relevance 1.13 Pain Relevance 0.27
Increased levels of ROS/RNS are associated with decreased antioxidant levels [63,64].
Positive_regulation (Increased) of RNS
4) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.05 Pain Relevance 0.07
Serum RNase increased by as much as 800 percent above normal in 69 percent of patients with pancreatic cancer.
Positive_regulation (increased) of Serum RNase associated with pancreatic cancer
5) Confidence 0.44 Published 1980 Journal Am. J. Surg. Section Abstract Doc Link 7350842 Disease Relevance 1.03 Pain Relevance 0.22
Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis?
Positive_regulation (evaluation) of serum ribonuclease associated with pancreatic cancer
6) Confidence 0.43 Published 1984 Journal Oncology Section Title Doc Link 6504493 Disease Relevance 0.43 Pain Relevance 0.09
Muscle RNA is also reduced by mechanisms involving increased RNase activities.
Positive_regulation (increased) of RNase in Muscle
7) Confidence 0.39 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784353 Disease Relevance 1.21 Pain Relevance 0.31
Increased DNase and RNase values were found not only in a notable proportion of pancreatic cancer, but also in chronic pancreatitis and extra-pancreatic diseases.
Positive_regulation (Increased) of RNase associated with pancreatitis, pancreatic cancer and chronic pancreatitis
8) Confidence 0.27 Published 1985 Journal Tumori Section Abstract Doc Link 4082285 Disease Relevance 0.90 Pain Relevance 0.26
Serum ribonuclease (RNase) and deoxyribonuclease (DNase) were investigated in 18 control subjects, and in 22 patients with pancreatic cancer, 13 with chronic pancreatitis and 29 with extrapancreatic diseases in order to assess their clinical usefulness in pancreatic cancer diagnosis and to evaluate whether modifications were consensual and/or age-related.
Spec (investigated) Positive_regulation (investigated) of Serum ribonuclease associated with pancreatic cancer, disease and chronic pancreatitis
9) Confidence 0.27 Published 1985 Journal Tumori Section Abstract Doc Link 4082285 Disease Relevance 0.80 Pain Relevance 0.24
Ten micrograms of human cerebellar RNA, isolated with RNAwiz (Ambion), was treated with DNase (Ambion Turbo DNA-free) for 30 min at 37°C according to the manufacturer's instructions, precipitated, and treated with RNase A/T1 (Ambion) for 30 min at 37°C in RNase buffer (300 mM NaCl, 10 mM Tris, pH 7.4, and 5 mM EDTA).
Positive_regulation (treated) of RNase
10) Confidence 0.17 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Elevated RNase activity has previously been described in the circulation of cancer patients, and NPC was found to be associated with disturbances in the integrity of cell-free circulating RNA.
Positive_regulation (Elevated) of RNase associated with nasopharynx cancer and cancer
11) Confidence 0.15 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.31 Pain Relevance 0.08

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