INT15540

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 19.01
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelet 7
HGF 2
plasma 1
pericytes 1
fingers 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 85 99.80 Very High Very High Very High
Inflammation 120 99.60 Very High Very High Very High
Angina 9 98.16 Very High Very High Very High
metalloproteinase 17 94.56 High High
fibrosis 74 93.60 High High
psoriasis 1 90.32 High High
antagonist 8 90.24 High High
addiction 36 86.76 High High
Chronic pancreatitis 33 81.20 Quite High
iatrogenic 3 80.88 Quite High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 77 99.96 Very High Very High Very High
Hypoxia 54 99.64 Very High Very High Very High
INFLAMMATION 147 99.60 Very High Very High Very High
Sickle Cell Anemia 126 99.56 Very High Very High Very High
Tricuspid Valve Insufficiency 102 99.42 Very High Very High Very High
Apoptosis 57 99.12 Very High Very High Very High
Disease 135 98.48 Very High Very High Very High
Fibrosis 80 98.44 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 98.40 Very High Very High Very High
Hematoma 2 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POD 1 upregulation of PDGFA, ERG1, and HMGB1 mRNA correlated significantly with worse prognosis.
Positive_regulation (upregulation) of PDGFA
1) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.11
CRP mRNA was upregulated first, with PDGFA, TNF-?
Positive_regulation (upregulated) of PDGFA
2) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.80 Pain Relevance 0.11
Similarly, several studies had reported that PDGF isoforms and their receptors were upregulated during pathologic fibroproliferative diseases in humans and in murine models by different types of impairment (e.g. radiation- [19,20]/bleomycin- [11] induced fibrosis, idiopathic pulmonary fibrosis [21]) vindicating the importance of the PDGF/PDGFR system in proliferative diseases.
Positive_regulation (upregulated) of PDGF associated with fibrosis, pulmonary fibrosis and disease
3) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.54 Pain Relevance 0.13
MUC1 and PDGFA were upregulated at POD 3 (p = 0.048 and 0.045), followed by recovery from POD 5 to POD 14.
Positive_regulation (upregulated) of PDGFA
4) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.24 Pain Relevance 0.03
In addition, activated platelets might be a source of increased plasma PDGF levels in sickle cell disease [22].
Positive_regulation (increased) of PDGF in platelets associated with sickle cell anemia
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.16 Pain Relevance 0.09
Under normal conditions PDGF-AA induces ?
Positive_regulation (induces) of PDGF
6) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.68 Pain Relevance 0.34
Furthermore, the negative association of VEGF with tricuspid regurgitation velocity appears only after adjustment for PDGF concentration.
Positive_regulation (adjustment) of PDGF associated with tricuspid valve insufficiency
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.01 Pain Relevance 0
Elevated levels of platelet-derived growth factor (PDGF), endothelin-1 (ET-1), ?
Positive_regulation (levels) of platelet-derived growth factor in platelet
8) Confidence 0.33 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2323011 Disease Relevance 1.10 Pain Relevance 0.06
Elevated levels of platelet-derived growth factor (PDGF), endothelin-1 (ET-1), ?
Positive_regulation (levels) of PDGF in platelet
9) Confidence 0.33 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2323011 Disease Relevance 1.10 Pain Relevance 0.06
Then, these unfragmented megakaryocytes stimulate the production of platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) by endothelial cells, resulting in angiogenesis and endothelial hyperplasia which is manifested as clubbing of fingers and toes [7].
Positive_regulation (derived) of PDGF in fingers associated with hyperplasia
10) Confidence 0.31 Published 2008 Journal Cases J Section Body Doc Link PMC2567299 Disease Relevance 1.69 Pain Relevance 0
One recent study has found that induction of the PDGF pathway in human LEC resulted in a PI3K/Akt pathway dependent increase in cellular migration [21].
Positive_regulation (induction) of PDGF
11) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.55 Pain Relevance 0
This event triggers a complex adaptive response including transcription of angiogenesis-stimulating factors VEGF (vascular endothelial growth factor) directed to receptors on microvascular endothelial cells and PDGF (platelet-derived growth factor) directed to microvascular supporting pericytes.
Positive_regulation (directed) of PDGF in pericytes
12) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 1.50 Pain Relevance 0
PGE2 induced by COX-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) Promoting angiogenesis (increased VEGF, bFGF, and PDGF production), 2) Anti-apoptosis mechanism (via increased bcl-2 and Akt activity), 3) Stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) Decreased immune surveillance (decreased cytokine production and NK activity).
Positive_regulation (increased) of PDGF associated with metalloproteinase, apoptosis, metastasis and cytokine
13) Confidence 0.17 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.73 Pain Relevance 0.28
AMG706 is an oral, multikinase inhibitor with antiangiogenic activity that selectively targets VEGF, PDGF (platelet-derived growth factor), and Kit receptors.
Positive_regulation (targets) of PDGF in platelet
14) Confidence 0.15 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 0.64 Pain Relevance 0
Similarly, it has been shown that both pro- and anti-inflammatory cytokines, such as PDGF and TGFbeta, activate PSC and thus contribute to pancreatic fibrogenesis [22].
Positive_regulation (activate) of PDGF associated with fibrosis, inflammation, primary sclerosing cholangitis and cytokine
15) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.54 Pain Relevance 0.31
The fibrin network within the hematoma traps platelets that, in turn, release various bioactive factors, including platelet derived growth factor (PDGF) and transforming growth factor (TGF)-?
Positive_regulation (derived) of PDGF in platelets associated with hematoma and tumor necrosis factor receptor-associated periodic syndrome
16) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.69 Pain Relevance 0.06
For tumors to attain a size beyond a few millimeters requires a process known as angiogenesis.25,26 Angiogenesis is a physiological process that depends on a well orchestrated balance of angiogenic factors and inhibitors that control the growth of microvessel sprouts via migration and proliferation of endothelial cells.27 When dysregulation of this process occurs, it may provide a suitable milieu for the initiation and maintenance of certain chronic disease states such psoriasis,28 ocular neovascularization29 and atherosclerosis.30 In addition, pathological angiogenesis has been shown to be a hallmark of certain tumor types such as GBM, colorectal carcinoma, breast and renal cell carcinomas.31 Tumor-associated neo-vascularization differs from physiological angiogenesis, characterized by a substantial increase in the proliferation activity of endothelial cells that are structurally “leaky”.32 Tipping the scales in favor of a proangiogenic state requires upregulation of factors such as VEGF-A, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF2).33–35 Additional pathways implicated in tumor angiogenesis are angiopoietin and Notch.36 Enzymes such as metalloproteinase and serine proteinase have been shown to be involved in the induction and suppression of angiogenesis by degrading the extracellular matrix.37 These have all been identified as possible substrates for therapeutic intervention.
Positive_regulation (upregulation) of PDGF in platelet associated with psoriasis, renal cancer, colon cancer, increased venous pressure under development, cancer, glioblastoma, metalloproteinase, pathologic neovascularization and chronic disease
17) Confidence 0.08 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 1.49 Pain Relevance 0.09
However, a laboratory analysis of human PRP samples demonstrated increased concentrations of PDGF, TGFbeta, VEGF, and EGF, while not showing an increase in IGF-1 [25].
Positive_regulation (increased) of PDGF
18) Confidence 0.07 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.22 Pain Relevance 0.05
Hypoxia can also lead to increased production of other pro-angiogenic molecules such as nitric oxide synthase, platelet-derived growth factor (PDGF), transforming growth factors alpha and beta, basic fibroblastic growth factor (bFGF), and a class of protein growth factors called the angiopoietins.
Positive_regulation (increased) of PDGF in platelet associated with hypoxia
19) Confidence 0.07 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895781 Disease Relevance 0.80 Pain Relevance 0
Growth factor stimulating activity of LLL was demonstrated in both in vitro and in vivo experiments in which augmentation of FGF-2, PDGF and IGF-1 was observed [36,37,107].
Positive_regulation (augmentation) of PDGF
20) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2830167 Disease Relevance 0.57 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox