INT15541

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 11 100.00 Very High Very High Very High
narcan 4 90.68 High High
Intracerebroventricular 1 90.40 High High
methadone 1 76.36 Quite High
opiate 7 75.00 Quite High
Endogenous opioid 2 75.00 Quite High
addiction 2 60.68 Quite High
tolerance 2 60.08 Quite High
analgesia 1 58.12 Quite High
anesthesia 1 57.72 Quite High
Disease Link Frequency Relevance Heat
Death 5 98.38 Very High Very High Very High
Apoptosis 9 95.52 Very High Very High Very High
Leukemia 1 78.24 Quite High
Recurrence 2 63.20 Quite High
Opiate Addiction 1 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The magnitude of MACH reduction was significantly increased with the cumulative duration of stimulation.
Positive_regulation (increased) of Negative_regulation (reduction) of MACH associated with halothane
1) Confidence 0.31 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1736702 Disease Relevance 0 Pain Relevance 0.88
The initiator caspase-8 was not altered, but FLIP(L) (Fas-associated protein with death domain-like interleukin-1beta-converting enzyme-inhibitory protein), a dominant inhibitor of caspase-8, was increased in LT addicts (19%).
Positive_regulation (increased) of Negative_regulation (inhibitor) of caspase-8 associated with death
2) Confidence 0.30 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 1.23 Pain Relevance 0.43

General Comments

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