INT15543

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 25.60
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
HeLa 2
plasma 1
cleavage 1
HEp-2 1
vertebrae 1
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 11 100.00 Very High Very High Very High
Inflammation 171 99.48 Very High Very High Very High
cINOD 20 99.00 Very High Very High Very High
narcan 4 96.76 Very High Very High Very High
diclofenac 106 94.16 High High
cytokine 56 93.28 High High
Endogenous opioid 2 88.40 High High
cerebral cortex 27 83.40 Quite High
Nerve growth factor 6 82.68 Quite High
analgesia 1 77.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1239 100.00 Very High Very High Very High
Death 197 99.92 Very High Very High Very High
INFLAMMATION 201 99.48 Very High Very High Very High
Pheochromocytoma 66 99.44 Very High Very High Very High
Overweight 22 99.44 Very High Very High Very High
Cancer 719 99.20 Very High Very High Very High
Eosinophilic Esophagitis 106 98.60 Very High Very High Very High
Neuroblastoma 103 98.56 Very High Very High Very High
Scoliosis 2 97.84 Very High Very High Very High
Chronic Lymphoid Leukemia 42 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that embryonic cortical precursors are heterogeneous with respect to cell surface Fas expression and the co-expression of the anti-apoptotic protein FLIP (FLICE/caspase-8 interacting protein).
Gene_expression (expression) of caspase-8 associated with apoptosis
1) Confidence 0.75 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.42 Pain Relevance 0.07
Previously, we found significant differences in the frequency of HIC1 and CASP8 methylation between VHL-associated and sporadic phaeochromocytomas, but in this study we did not identify any further differentially methylated genes.
Gene_expression (methylation) of CASP8
2) Confidence 0.59 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.26 Pain Relevance 0
Thus, TSP1, CASP8, HIC1, DcR1, DcR2 and DR4 and RASSF1 were methylated frequently in both tumour types (Astuti et al. 2001c, Margetts et al. 2005).
Gene_expression (methylated) of CASP8 associated with cancer
3) Confidence 0.59 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.51 Pain Relevance 0.06
Our results indicate that embryonic cortical precursors are heterogeneous with respect to cell surface Fas expression and the co-expression of the anti-apoptotic protein FLIP (FLICE/caspase-8 interacting protein).
Gene_expression (expression) of caspase-8 associated with apoptosis
4) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.41 Pain Relevance 0.07
Our results indicate that embryonic cortical precursors are heterogeneous with respect to cell surface Fas expression and the co-expression of the anti-apoptotic protein FLIP (FLICE/caspase-8 interacting protein).
Gene_expression (expression) of FLICE associated with apoptosis
5) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.41 Pain Relevance 0.07
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Gene_expression (expression) of caspase 8
6) Confidence 0.49 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 0.99 Pain Relevance 0.08
MACH was decreased markedly in stimulated animals (TCES, n = 10) in comparison with sham-operated nonstimulated rats (controls, n = 10): MACH = 0.60 +/- 0.15, mean +/- SD, versus 1.07 +/- 0.05 vol%, P less than 0.001.
Gene_expression (decreased) of MACH associated with halothane
7) Confidence 0.45 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1736702 Disease Relevance 0 Pain Relevance 0.85
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of CASP8
8) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.50 Pain Relevance 0.03
Additionally, it was reported that miR-19b-1 may also target caspase 8 (CASP8), death-associated protein kinase 3 (DAPK3), and programmed cell death 1 ligand 2 (PDCD1LG2), all genes known to be involved in apoptosis, further suggesting the anti-apoptotic function of the miR-17-92 cluster in cancer.
Gene_expression (target) of caspase 8 associated with cancer, apoptosis and death
9) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.00 Pain Relevance 0
Additionally, it was reported that miR-19b-1 may also target caspase 8 (CASP8), death-associated protein kinase 3 (DAPK3), and programmed cell death 1 ligand 2 (PDCD1LG2), all genes known to be involved in apoptosis, further suggesting the anti-apoptotic function of the miR-17-92 cluster in cancer.
Gene_expression (target) of CASP8 associated with cancer, apoptosis and death
10) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.05 Pain Relevance 0
Intervertebral disks from 28 donors (age 12-70 years) suffering from scoliosis, vertebrae fracture or disk degeneration were scored histologically for degeneration and analyzed for gene expression of FasL/Fas, TRAIL/DR4, TNF-alpha/TNFR1 and caspase 8.
Spec (analyzed) Gene_expression (expression) of caspase 8 in vertebrae associated with scoliosis
11) Confidence 0.27 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.83 Pain Relevance 0.12
Gene expression of TRAIL (P=0.002) and caspase 8 (P=0.027) significantly correlated with degeneration.
Gene_expression (expression) of caspase 8
12) Confidence 0.24 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.73 Pain Relevance 0.10
The present data report that UVB irradiation induced levels of cleaved caspase-8 and -9.
Gene_expression (cleaved) of caspase-8
13) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.13 Pain Relevance 0
We report an array of new potential markers of inflammatory responsiveness to NSAID therapy in overweight subjects that include PBMC expression of ANXA1 and caspase 8, as well as plasma concentrations of 5,6-DHET.
Gene_expression (expression) of caspase 8 in plasma associated with inflammation, cinod and overweight
14) Confidence 0.21 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.86 Pain Relevance 0.45
Expression of caspase-8 was observed in the FV treated cells when compared to untreated cells, which in turn was believed to activate the procaspase-3 to active caspase-3 [29].
Gene_expression (Expression) of caspase-8
15) Confidence 0.20 Published 2006 Journal J Carcinog Section Body Doc Link PMC1705806 Disease Relevance 1.14 Pain Relevance 0
Expression data was available for the following Bcl-2 genes: Bcl-2, Bfl-1 (BCL2A1), Bik, Bcl-w (BCL2L2), Bax, BCLAF1 (Bcl2-associated transcription factor 1); and for the following caspase genes: Caspase-1, Caspase-2, Caspase-3, Caspase-6, Caspase-8, Caspase-9, Caspase-10.
Gene_expression (genes) of Caspase-8
16) Confidence 0.19 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.33 Pain Relevance 0
Novel candidate markers of inflammatory modulation included PBMC expression of annexin A1 and caspase 8, and the arachidonic acid metabolite 5,6-DHET.


Gene_expression (expression) of caspase 8 associated with inflammation
17) Confidence 0.18 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2837611 Disease Relevance 1.10 Pain Relevance 0.52
Immunoblot analysis of Caspase-8 and Caspase-3 in HEp-2 and HeLa cells on exposure to FV (2 ?
Gene_expression (analysis) of Caspase-8 in HeLa
18) Confidence 0.17 Published 2006 Journal J Carcinog Section Body Doc Link PMC1705806 Disease Relevance 0.40 Pain Relevance 0
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Gene_expression (expression) of caspase 8
19) Confidence 0.17 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.05 Pain Relevance 0.08
Apoptosis was examined by propidium iodide staining, confirmed by the expression of caspase-8 and caspase-3, down regulation of Bcl-2 expression and DNA fragmentation in treated cells, when compared to untreated HEp2 and HeLa cells.
Gene_expression (expression) of caspase-8 in HeLa associated with apoptosis
20) Confidence 0.15 Published 2006 Journal J Carcinog Section Abstract Doc Link PMC1705806 Disease Relevance 0.27 Pain Relevance 0

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