INT15544

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.83
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
MCF-7 1
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 11 100.00 Very High Very High Very High
narcan 4 98.46 Very High Very High Very High
rheumatoid arthritis 67 98.08 Very High Very High Very High
cINOD 6 94.72 High High
Arthritis 4 88.64 High High
Endogenous opioid 2 75.60 Quite High
Intracerebroventricular 1 75.44 Quite High
COX-2 inhibitor 1 73.44 Quite High
analgesia 1 64.36 Quite High
anesthesia 1 63.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 183 100.00 Very High Very High Very High
Breast Cancer 8 99.24 Very High Very High Very High
Rheumatoid Arthritis 67 98.08 Very High Very High Very High
Colon Cancer 12 91.44 High High
Experimental Arthritis 1 89.68 High High
Arthritis 4 85.24 High High
Parkinson's Disease 2 84.12 Quite High
Cancer 44 82.96 Quite High
Death 14 75.00 Quite High
Necrosis 4 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In TCES animals, naloxone administration restored MACH values to the levels of controls but failed to affect MACH in controls.
Neg (failed) Regulation (affect) of MACH associated with narcan and halothane
1) Confidence 0.41 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1736702 Disease Relevance 0 Pain Relevance 0.90
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Regulation (changes) of caspase 8
2) Confidence 0.39 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.00 Pain Relevance 0.08
Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.
Regulation (dependent) of caspase-8 in MCF-7 associated with breast cancer and apoptosis
3) Confidence 0.27 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.95 Pain Relevance 0.25
Additional intracellular factors leading to TRAIL-resistance affect the caspase 8/c-FLIP ratio, such as loss of caspase 8 and caspase 10 due to mutations or gene methylation, CARP-dependent degradation of active caspase 8 and changes in caspase 8 or c-FLIP expression levels.
Regulation (affect) of caspase 8
4) Confidence 0.13 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.06 Pain Relevance 0.07
Upregulation of anti-apoptotic molecules belonging to the Bcl family and of the caspase-8 inhibitor FLIP has been repeatedly reported in RA [12].
Regulation (Upregulation) of caspase-8 associated with rheumatoid arthritis and apoptosis
5) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 1.37 Pain Relevance 0.32
The expression levels of pro-caspase-8 were not changed after NCTD treatment (Figure 6B).
Neg (not) Regulation (changed) of pro-caspase-8
6) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.90 Pain Relevance 0
The expression levels of pro-caspase-8 were not changed after NCTD treatment.


Neg (not) Regulation (changed) of pro-caspase-8
7) Confidence 0.02 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2987898 Disease Relevance 0.55 Pain Relevance 0

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