INT155455

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.50
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
spinal cord 3
DRG 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 100.00 Very High Very High Very High
Spinal cord 14 98.76 Very High Very High Very High
intrathecal 2 98.60 Very High Very High Very High
Sciatic nerve 2 96.68 Very High Very High Very High
Neuropathic pain 6 79.48 Quite High
Peripheral nerve injury 2 78.28 Quite High
Pain 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 10 100.00 Very High Very High Very High
Necrosis 6 83.88 Quite High
Cancer 6 83.52 Quite High
Neuropathic Pain 6 79.48 Quite High
Nervous System Injury 2 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of IL-6 mRNA in spinal cord associated with eae, spinal cord and intrathecal
1) Confidence 0.31 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.25 Pain Relevance 0.88
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Negative_regulation (inhibited) of in DRG Phosphorylation (phosphorylation) of IL-6 mRNA in spinal cord associated with eae, spinal cord and intrathecal
2) Confidence 0.11 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.25 Pain Relevance 0.88

General Comments

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