INT155460

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 2.39
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Tnfrsf1a, Nfkb1) nucleus (Tnfrsf1a, Nfkb1) mitochondrion (Nfkb1)
DNA binding (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1)
Anatomy Link Frequency
DRG 2
Tnfrsf1a (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuropathic pain 6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
peripheral nerve injury 2 98.64 Very High Very High Very High
spinal cord 14 98.52 Very High Very High Very High
Eae 10 96.44 Very High Very High Very High
Sciatic nerve 2 79.84 Quite High
intrathecal 2 79.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Neuropathic Pain 6 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Nervous System Injury 2 98.20 Very High Very High Very High
Injury 10 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, these data suggest that TNFR1 induces IL-6 upregulation and neuropathic pain through NF-kappaB, but not p38 MAPK activation in the spinal cord and DRG and that the NF-kappaB/IL-6 pathways in the DRG may be less dependent on TNFR1 than the spinal cord pathway.
TNFR1 Positive_regulation (induces) of Positive_regulation (upregulation) of NF-kappaB in DRG associated with neuropathic pain and spinal cord
1) Confidence 0.42 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.10 Pain Relevance 0.85
Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model.
Tumor necrosis factor receptor 1 Positive_regulation (induces) of Positive_regulation (upregulation) of NF-kappaB associated with pain, necrosis and neuropathic pain
2) Confidence 0.42 Published 2009 Journal Eur J Pain Section Title Doc Link 18938092 Disease Relevance 1.28 Pain Relevance 0.97

General Comments

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