INT155485

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 3.73
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 24
leukocyte 2
T cells 2
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 2 95.92 Very High Very High Very High
cINOD 27 88.60 High High
cytokine 64 85.56 High High
Inflammation 51 78.16 Quite High
corticosteroid 3 64.72 Quite High
chemokine 44 13.28 Low Low
pruritus 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hookworm Infection 105 98.88 Very High Very High Very High
Phototoxic Dermatitis 96 97.56 Very High Very High Very High
Adhesions 21 95.88 Very High Very High Very High
Dermatitis 16 93.44 High High
Infection 108 91.84 High High
INFLAMMATION 86 88.40 High High
Helminth Infection 12 84.68 Quite High
Contact Dermatitis 16 84.40 Quite High
Hyperplasia 6 80.32 Quite High
Photosensitivity Disorders 72 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, (i) CD86 expression was not affected by the chosen irradiation conditions, (ii) increased CD86 expression induced by allergens was independent of irradiation and (iii) no PBMDC activation was observed with the non-allergenic control.
Neg (not) Regulation (not) of Gene_expression (expression) of CD86 in CD86
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.36 Pain Relevance 0
As expected, no relevant modulation of the CD86 expression was detected with or without irradiation and no cytotoxic effect was observed up to the highest test concentration.
Neg (no) Regulation (modulation) of Gene_expression (expression) of CD86 in CD86
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.09 Pain Relevance 0
The impact of irradiation on the chosen biomarkers (CD86, CD83 and HLA-DR) expression was examined.
Spec (examined) Regulation (impact) of Gene_expression (expression) of CD86 in CD86
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.13 Pain Relevance 0
On the other hand, KP alone (without irradiation) had no relevant effect on the CD86 expression or on the cell viability.
Neg (no) Regulation (effect) of Gene_expression (expression) of CD86 in CD86
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0.09
Indeed, KP induced a dose-dependent increase of CD86 expression after irradiation whereas without irradiation it had no relevant effect on the CD86 expression or on the cell viability.
Neg (no) Regulation (effect) of Gene_expression (expression) of CD86 in CD86
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.22 Pain Relevance 0.08
Marked T cell proliferation in the coculture was completely abrogated by mAb blockade of CD86, confirming that costimulatory properties are conferred on ECs by CD86 expression.
Regulation (conferred) of Gene_expression (expression) of CD86 in CD86
6) Confidence 0.44 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.55 Pain Relevance 0.14
In contrast, (i) CD86 expression was not affected by the chosen irradiation conditions, (ii) increased CD86 expression induced by allergens was independent of irradiation and (iii) no PBMDC activation was observed with the non-allergenic control.
Neg (not) Regulation (affected) of Gene_expression (expression) of CD86 in CD86
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.36 Pain Relevance 0
Cell viability and the modulation of CD86 expression (?
Regulation (modulation) of Gene_expression (expression) of CD86 in CD86
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0
CPZ, a known photosensitizer with photoallergenic and phototoxic properties, was tested with and without irradiation and the induced modulation of CD86, CD83 and HLA-DR expressions as well as cell viability were measured by flow cytometry and compared 48 h after treatment.
Regulation (modulation) of Gene_expression (expressions) of CD86 in CD86
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0 Pain Relevance 0
These data suggest a novel role for CD86 expression on the microvasculature, whereby ligation of CTLA-4 on CD4 T cells by CD86 on islet ECs is key to the adhesion of recently activated T cells.
Regulation (role) of Gene_expression (expression) of CD86 in T cells associated with adhesions
10) Confidence 0.26 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18941200 Disease Relevance 0.49 Pain Relevance 0.12
In order to assess the effect of the reduced expression of CD86 and antigen presentation molecules on dendritic cells from Necator-infected patients, co-incubation with heterologous PBMCs was performed as a mixed leukocyte response.
Regulation (effect) of Gene_expression (expression) of CD86 in leukocyte
11) Confidence 0.23 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.34 Pain Relevance 0
While this is indeed the case for matured DCs from non-infected donors, mDCs from Necator-infected individuals have a down-regulated expression of antigen-presenting, costimulatory (CD86) molecules, and CD11c, with the CD14 still present on the cell surface.
Regulation (regulated) of Gene_expression (expression) of CD86 in CD86
12) Confidence 0.23 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0.12
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Regulation (regulated) of Gene_expression (expression) of CD86 in CD86 associated with hookworm infection
13) Confidence 0.23 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.57 Pain Relevance 0
In this setting, HMB-PP-stimulated but not unstimulated co-cultures produced soluble factors that crossed the separating membrane and down-modulated CD14 as well as induced expression of CD40, CD86, and HLA-DR.
Neg (not) Regulation (modulated) of Gene_expression (expression) of CD86 in CD86
14) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.04

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