INT155486

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 16
Total Number 44
Disease Relevance 14.60
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 81
macrophages 4
T cells 2
monocytes 1
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 163 99.98 Very High Very High Very High
abatacept 1 95.92 Very High Very High Very High
chemokine 110 93.60 High High
cINOD 96 93.20 High High
Inflammation 310 92.80 High High
agonist 63 91.84 High High
rheumatoid arthritis 148 90.16 High High
Inflammatory marker 1 75.72 Quite High
psoriasis 2 69.68 Quite High
Arthritis 6 67.36 Quite High
Disease Link Frequency Relevance Heat
Adhesions 48 100.00 Very High Very High Very High
Hookworm Infection 70 99.46 Very High Very High Very High
Photoallergic Dermatitis 145 99.26 Very High Very High Very High
Phototoxic Dermatitis 348 97.88 Very High Very High Very High
Occupational Lung Diseases 18 97.32 Very High Very High Very High
Hypersensitivity 64 96.88 Very High Very High Very High
Infection 285 93.36 High High
Photosensitivity Disorders 261 93.36 High High
Adenocarcinoma 180 92.84 High High
INFLAMMATION 431 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, a marked increase in CD86 expression was observed under those same conditions (Fig. 3C).
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0.07
Likewise, NI induced very similar dose-dependent increases of the CD86 expression with or without irradiation (?
Positive_regulation (increases) of Gene_expression (expression) of CD86 in CD86
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.08 Pain Relevance 0
In contrast, (i) CD86 expression was not affected by the chosen irradiation conditions, (ii) increased CD86 expression induced by allergens was independent of irradiation and (iii) no PBMDC activation was observed with the non-allergenic control.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.35 Pain Relevance 0
This represents a very significant increase in CD86 expression compared to the low ?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.06 Pain Relevance 0
Higher doses induced a dose-dependent increase in CD86 expression (?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0
OLQ, a photoallergenic feed additive and antibiotic, induced under radiation conditions a dose-related increase in CD86 expression (?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
6) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.16 Pain Relevance 0.08
A dose-related increase in CD86 expression (?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
7) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.08 Pain Relevance 0
CPZ, a known photosensitizer with photoallergenic and phototoxic properties, was tested with and without irradiation and the induced modulation of CD86, CD83 and HLA-DR expressions as well as cell viability were measured by flow cytometry and compared 48 h after treatment.
Positive_regulation (induced) of Gene_expression (expressions) of CD86 in CD86
8) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0 Pain Relevance 0
No relevant increase in CD86 expression could be detected at irradiation doses <1 J/cm2.
Neg (No) Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
9) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0
6-MC (responsible for photocontact dermatitis reactions) induced a dose-dependent increase in CD86 expression after irradiation (>40% ?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86 associated with photoallergic dermatitis
10) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.10 Pain Relevance 0
All tested photosensitizers induced a significant and dose-dependent increase of CD86 expression after irradiation compared to non-irradiated controls.
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
11) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.39 Pain Relevance 0
Using our assay, MA a known allergenic and photoallergenic fragrance [19], [26] induced a dose-related increase in CD86 expression with or without irradiation, the increase being significantly higher after irradiation.
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
12) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0
Indeed, KP induced a dose-dependent increase of CD86 expression after irradiation whereas without irradiation it had no relevant effect on the CD86 expression or on the cell viability.
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
13) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.23 Pain Relevance 0.08
Using our test protocol, the photoallergenic feed additive OLQ induced significant and dose-related increases in CD86 expression and cytotoxicity was detected at the highest test concentration.
Positive_regulation (increases) of Gene_expression (expression) of CD86 in CD86
14) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.15 Pain Relevance 0.07
NI induced similar dose-dependent increases of the CD86 expression under both conditions and irradiation had no influence on its relatively weak cytotoxicity.
Positive_regulation (increases) of Gene_expression (expression) of CD86 in CD86
15) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.08 Pain Relevance 0
In contrast, non-irradiated OLQ treatment resulted in limited CD86 modulation (?
Positive_regulation (resulted) of Gene_expression (modulation) of CD86 in CD86
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.17 Pain Relevance 0.07
The analysis of an extensive data pool over multiple projects, extensive time periods and different laboratory personnel revealed a very stable basal expression of CD86 among donors (n?
Positive_regulation (stable) of Gene_expression (expression) of CD86 in CD86
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.06 Pain Relevance 0
Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.
Positive_regulation (increases) of Gene_expression (expression) of CD86 in CD86
18) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.28 Pain Relevance 0
In our test, irradiated SPFX induced a relevant CD86 modulation already at low concentrations (?
Positive_regulation (induced) of Gene_expression (modulation) of CD86 in CD86
19) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.29 Pain Relevance 0.07
Higher doses induced a dose-dependent increase in CD86 expression (?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
20) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0

General Comments

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