INT15549

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Context Info
Confidence 0.38
First Reported 1985
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 2.55
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
sensory neurons 2
cardiomyocytes 2
glial cells 2
liver 2
thyroid 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 98 100.00 Very High Very High Very High
tetrodotoxin 11 99.62 Very High Very High Very High
Glutamate receptor 6 97.60 Very High Very High Very High
Paracetamol 3 97.12 Very High Very High Very High
nMDA receptor 3 96.08 Very High Very High Very High
lidocaine 1 95.24 Very High Very High Very High
Glutamate 8 91.68 High High
conotoxin 1 89.56 High High
nMDA receptor antagonist 2 87.48 High High
Calcium channel 7 87.44 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 32 96.40 Very High Very High Very High
Hypertrophy 92 95.64 Very High Very High Very High
Stress 17 93.68 High High
Coronary Heart Disease 21 93.24 High High
Ganglion Cysts 53 80.76 Quite High
Hypoxia 146 79.96 Quite High
Injury 2 74.80 Quite High
Necrosis 1 69.68 Quite High
Cv Unclassified Under Development 21 68.64 Quite High
Hepatotoxicity 1 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is reflected in a biphasic rise in cytosolic [Ca2+]i and, (after ?
Regulation (reflected) of Positive_regulation (rise) of Ca2
1) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.21 Pain Relevance 0.03
These studies lead to the notion that the Ca2+ influx through LCCs becomes less effective in triggering RyR Ca2+ release [13].
Regulation (effective) of Positive_regulation (triggering) of Ca2
2) Confidence 0.38 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 1.00 Pain Relevance 0.03
In spite of their important regulatory functions under normal physiological conditions, accumulated levels of Ca2+ are observed to result in the proteolysis of crystallins associated with cataractogenesis.
Regulation (result) of Positive_regulation (accumulated) of Ca2
3) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.17 Pain Relevance 0
Additionally, R 56865 did not affect the Ca2(+)-induced contractile response.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (induced) of Ca2
4) Confidence 0.24 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2055238 Disease Relevance 0 Pain Relevance 0.22
Brief (1 s) tetanization of Schaffer collaterals produced increases in intracellular Ca2+ levels in glial cells that were dependent on the frequency of stimulation (> or =50 Hz) and on synaptic transmission (abolished by tetrodotoxin).
Regulation (dependent) of Positive_regulation (increases) of Ca2 in glial cells associated with tetrodotoxin
5) Confidence 0.24 Published 2001 Journal Hippocampus Section Abstract Doc Link 11345120 Disease Relevance 0 Pain Relevance 0.93
Tetrodotoxin (10(-6) M) had no effect on the ouabain-induced increase in both [3H]ACh release and [Ca2+]i but abolished the increase in 22Na+ uptake and partially inhibited the depolarizing effect.
Neg (no) Regulation (effect) of Positive_regulation (increase) of Ca2 associated with tetrodotoxin
6) Confidence 0.23 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1737982 Disease Relevance 0 Pain Relevance 0.10
Neither extracellular Ca2+ nor ATP depletion influenced significantly the carbonyl cyanide m-chlorophenylhydrasone-sensitive intracellular Ca2+ elevation in neurons loaded with Ca2+ via vanilloid 1 receptor stimulation.
Neg (Neither) Regulation (influenced) of Positive_regulation (elevation) of Ca2 in neurons
7) Confidence 0.23 Published 2000 Journal Neuroscience Section Abstract Doc Link 10619474 Disease Relevance 0.14 Pain Relevance 0.49
Tetrodotoxin, as well as the removal of extracellular Na+ ions, failed to affect maitotoxin-induced increase of intrasynaptosomal Ca2+ levels.
Neg (failed) Regulation (affect) of Positive_regulation (increase) of Ca2 associated with tetrodotoxin
8) Confidence 0.23 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2378876 Disease Relevance 0 Pain Relevance 0.10
Mitochondrial Ca2+ uptake was minimally affected by the toxins, and only CCl4 affected Ca2+ accumulation by liver microsomes.
Regulation (affected) of Positive_regulation (accumulation) of Ca2 in liver
9) Confidence 0.23 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 4021997 Disease Relevance 0.20 Pain Relevance 0.27
In the present study, the Na(+)-ionophore, monensin, was used to investigate the interrelationship between changes in intracellular Na+ concentration ([Na+]i) and elevation of cytosolic Ca2+ concentration ([Ca2+]i) in FRTL-5 thyroid cells.
Regulation (changes) of Spec (investigate) Positive_regulation (elevation) of Ca2 in thyroid
10) Confidence 0.17 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2223796 Disease Relevance 0 Pain Relevance 0.09
To test whether the intracellular store of Ca2+ contributes to OAG-induced Ca2+ transients in TRPV1-expressing HEK 293 cells, we blocked Ca2+ release from internal store by treating with 1 ?
Spec (whether) Regulation (contributes) of Spec (whether) Positive_regulation (store) of Ca2 in internal
11) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.31 Pain Relevance 0.42
1A-AR-AB to neonatal cardiomyocytes affected intracellular Ca2+ at two different levels, namely the acute, short-term elevation of intracellular Ca2+, and the increased transcript expression of Cacna1c [5].
Regulation (affected) of Positive_regulation (elevation) of Ca2 in cardiomyocytes
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.50 Pain Relevance 0.11
is involved in the ET-1-mediated enhancement of capsaicin-induced Ca2+ increases in sensory neurons, but which did not show that TRPV1 is the target for PKC-?
Regulation (involved) of Positive_regulation (increases) of Ca2 in sensory neurons associated with qutenza
13) Confidence 0.05 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.13

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