INT155490

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 18
Disease Relevance 13.38
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
small intestine 1
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 5 89.80 High High
endometriosis 1 87.68 High High
Pain 7 81.92 Quite High
Inflammation 43 75.52 Quite High
imagery 19 72.48 Quite High
backache 1 55.00 Quite High
chemokine 81 54.04 Quite High
methotrexate 2 53.36 Quite High
Serotonin 12 53.08 Quite High
ischemia 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 759 100.00 Very High Very High Very High
Breast Cancer 566 100.00 Very High Very High Very High
Necrosis 18 99.88 Very High Very High Very High
Osteogenic Sarcomas 150 99.84 Very High Very High Very High
Injury 66 99.44 Very High Very High Very High
Pilomatrixoma 14 99.44 Very High Very High Very High
Adenosarcoma 10 99.14 Very High Very High Very High
Apoptosis 58 98.72 Very High Very High Very High
Carcinoma 97 97.76 Very High Very High Very High
Adenofibroma 7 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bridger et al suggested a role of Ki67 in organizing DNA, based on its localization to extranucleolar sites during early G1; these sites contain centromeric and satellite DNA.14 Ki67 is also known to bind to DNA.
Ki67 Binding (bind) of
1) Confidence 0.19 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.52 Pain Relevance 0
Mac-Callum and Hall suggested a structural role for Ki67 within the nucleolus, based on its ability to interact with other proteins and bind with RNA and DNA.14,15 They also suggested that Ki67 is an essential factor in the synthesis of ribosomes during cell division.15 Further studies should be conducted to elucidate the roles of Ki67 in cell proliferation and tumorigenesis.
Ki67 Binding (interact) of
2) Confidence 0.17 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.62 Pain Relevance 0
Indeed, proliferation of TEC was most abundant 7 days after I/R injury (Fig. 4f) as determined by staining for Ki67 (Fig. 4a).
Ki67 Spec (determined) Binding (staining) of associated with injury
3) Confidence 0.17 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 1.16 Pain Relevance 0.06
To determine the effect of the therapies on tumor cell apoptosis and proliferation, tumor sections were stained with antibodies recognizing cleaved caspase-3 and Ki67, respectively.
Ki67 Binding (recognizing) of associated with cancer and apoptosis
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781164 Disease Relevance 0.90 Pain Relevance 0
In this study, we noted that a higher baseline Ki-67 was associated with better response to chemotherapy, probably because a higher fraction of these proliferative tumors at initiation of chemotherapy were susceptible to chemotoxic effects.
Ki-67 Binding (associated) of associated with cancer
5) Confidence 0.15 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.43 Pain Relevance 0.03
Ki67 staining will continued to be used as a useful laboratory test to predict the prognosis of breast cancer patients since it is technically easier and more closely associated with clinical outcomes than DNA ploidy analysis or S phase measurement by flow cytometry.


Ki67 Binding (associated) of associated with breast cancer
6) Confidence 0.14 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.40 Pain Relevance 0
Ki67 has traditionally been recognized as a poor prognostic factor, but recent studies suggest that measurement of Ki67-positive cells during treatment will more effectively predict treatment efficacy for both anti-hormonal and chemotherapy. p53 mutations are found in 20–35% of human breast cancers and are associated with aggressive disease with poor clinical outcome when the DNA-binding domain is mutated.
Ki67 Binding (recognized) of associated with breast cancer and disease
7) Confidence 0.14 Published 2010 Journal Clinical Medicine Insights. Oncology Section Abstract Doc Link PMC2883240 Disease Relevance 0.40 Pain Relevance 0
We examined the conventional clinicopathologic factors including the six different biological factors (ER, PR, p53, c-erbB2, bcl-2, and Ki-67) by immunohistochemistry and evaluated their association with clinical outcomes.
Ki-67 Spec (examined) Binding (association) of
8) Confidence 0.14 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2217558 Disease Relevance 0.56 Pain Relevance 0.04
Fayyazi and colleagues have assessed expression of the cell proliferation associated antigen Ki 67 (MIB1) in 15 pilomatrixomas [11].
Ki 67 Binding (associated) of associated with pilomatrixoma
9) Confidence 0.13 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2633279 Disease Relevance 1.40 Pain Relevance 0
Chromogranin A appears to undergo a process of fragmentation, and the fragments detected by particular tests influence the resulting sensitivity.

4.3 Ki67

Ki67 Binding (influence) of
10) Confidence 0.13 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.48 Pain Relevance 0.06
Thus, both causal procedures and statistical tests strongly suggested that the associations among EGFR, p-AKT and Ki-67 in the OS patients fell into a mediation pattern.
Ki-67 Binding (associations) of associated with osteogenic sarcomas
11) Confidence 0.11 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717822 Disease Relevance 0.25 Pain Relevance 0
Adenosarcomas with sarcomatous overgrowth showed strong immunoreaction for Ki-67 and p53 and loss of CD10 and progesterone receptors immunostaining; in contrast, the immunoreaction for these tumor markers in typical adenosarcomas without sarcomatous overgrowth was similar to that of adenofibromas associated with favorable outcome and other benign lesions such as endometrial polyps and endometriosis.
Ki-67 Binding (immunoreaction) of associated with adenofibroma, endometriosis, endometriosis (extended), adenosarcoma and cancer
12) Confidence 0.11 Published 2009 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18941402 Disease Relevance 1.95 Pain Relevance 0.04
The study also found significant associations between EGFR and Ki-67 (p = 0.002), EGFR and p-AKT (p = 0.027), and p-AKT and Ki-67 controlling EGFR (p = 0.004).
Ki-67 Binding (associations) of
13) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717822 Disease Relevance 0.47 Pain Relevance 0
The study also found significant associations between EGFR and Ki-67 (p = 0.002), EGFR and p-AKT (p = 0.027), and p-AKT and Ki-67 controlling EGFR (p = 0.004).
Ki-67 Binding (associations) of
14) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717822 Disease Relevance 0.47 Pain Relevance 0
After the impact of EGFR on Ki-67 was accounted for by p-AKT, the relation between EGFR and Ki-67 was no longer significant (p = 0.381).
Ki-67 Binding (relation) of
15) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717822 Disease Relevance 0.43 Pain Relevance 0
In conclusion, the present study found an association between EGFR and cancer cell proliferation biomarker Ki-67 in OS patients, and this association was carried by the p-AKT.
Ki-67 Binding (association) of associated with cancer and osteogenic sarcomas
16) Confidence 0.07 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717822 Disease Relevance 0.77 Pain Relevance 0.13
In univariate analysis, tumor size, local invasion, tumor perforation, mitotic count, tumor cellularity, tumor necrosis, and Ki-67 index significantly influenced DFS in patients with small intestine GISTs after curative resection.
Ki-67 Binding (index) of in small intestine associated with necrosis and cancer
17) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1633731 Disease Relevance 1.18 Pain Relevance 0
Only nuclear staining was considered in the evaluation of ER, PR, p53, p63, and KI-67.
KI-67 Binding (evaluation) of
18) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1563460 Disease Relevance 0.97 Pain Relevance 0.06

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