INT155497

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1, Tenc1) signal transduction (Oprk1) signal transducer activity (Oprk1)
Oprk1 (Mus musculus)
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 10 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Kappa opioid receptor 4 98.72 Very High Very High Very High
Endogenous opioid 2 93.28 High High
Neuropeptide 2 91.04 High High
Disease Link Frequency Relevance Heat
Thymoma 4 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, on R1.1 cells, NEP activity was inhibited by kappa-opioid polypeptide dynorphin (10(-8)-10(-6) M) and by thiorphan (2 x 10(-4) M), a known inhibitor of NEP (30 min treatment).
kappa-opioid polypeptide dynorphin Negative_regulation (inhibitor) of NEP associated with dynorphin and opioid
1) Confidence 0.08 Published 2008 Journal Cell Biochem. Funct. Section Abstract Doc Link 18942066 Disease Relevance 0.17 Pain Relevance 0.75
In this study, on R1.1 cells, NEP activity was inhibited by kappa-opioid polypeptide dynorphin (10(-8)-10(-6) M) and by thiorphan (2 x 10(-4) M), a known inhibitor of NEP (30 min treatment).
kappa-opioid polypeptide dynorphin Negative_regulation (inhibited) of NEP associated with dynorphin and opioid
2) Confidence 0.08 Published 2008 Journal Cell Biochem. Funct. Section Abstract Doc Link 18942066 Disease Relevance 0.17 Pain Relevance 0.73

General Comments

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