INT155512

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 7.88
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Braf) plasma membrane (Braf) nucleus (Braf)
kinase activity (Braf) cytoplasm (Braf)
Anatomy Link Frequency
joint 1
P19 1
Braf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 99.32 Very High Very High Very High
Chronic pancreatitis 4 99.26 Very High Very High Very High
cytokine 50 98.80 Very High Very High Very High
rheumatoid arthritis 740 98.76 Very High Very High Very High
Glutamate 10 90.36 High High
spinal inflammation 100 89.60 High High
Arthritis 100 88.32 High High
Kinase C 10 84.40 Quite High
psoriasis 20 65.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 50 99.32 Very High Very High Very High
Pancreatitis 10 99.26 Very High Very High Very High
Arthritis 120 99.08 Very High Very High Very High
Rheumatoid Arthritis 740 98.76 Very High Very High Very High
Pancreatic Cancer 2 94.68 High High
Cancer 10 94.20 High High
Death 10 93.32 High High
Low Back Pain 100 89.60 High High
Sarcoma 30 73.52 Quite High
Psoriasis 20 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of BRAF leads to activation of MEK1 and/or MEK2.
Positive_regulation (Activation) of BRAF
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.66 Pain Relevance 0.38
Thus, we suggest that anti-BRAF autoantibodies could activate the MAP kinase pathway through BRAF, leading to pro-inflammatory cytokine production and joint inflammation.
Positive_regulation (activate) of BRAF in joint associated with inflammation, arthritis and cytokine
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.83 Pain Relevance 0.50
We propose a model to explain how autoantibodies to BRAF may activate BRAF (Figure 4).
Positive_regulation (activate) of BRAF
3) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.81 Pain Relevance 0.47
For each patient, we included one positive phosphorylation control (incubation of inactive MEK1 with BRAF in working buffer) and one negative control (incubation of inactive MEK1 with BRAF in working buffer in presence of 0.1 ?
Positive_regulation (incubation) of BRAF
4) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.16 Pain Relevance 0.08
BRAF activation is regulated by both its N and C terminal domains.
Positive_regulation (activation) of BRAF
5) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.70 Pain Relevance 0.37
Most anti-BRAF autoantibodies activate BRAF kinase activity.



Positive_regulation (activate) of BRAF kinase
6) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991030 Disease Relevance 0.40 Pain Relevance 0.20
We have demonstrated here that these autoantibodies activate BRAF, which is the first step in MAP kinase activation.
Positive_regulation (activate) of BRAF
7) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.93 Pain Relevance 0.50
Peptides P18 and P19 contain position 598 threonine and a position 601 serine residues which are the targets of phosphorylation during BRAF activation.
Positive_regulation (activation) of BRAF in P19
8) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.58 Pain Relevance 0.35
After immune complexe dissociation, autoantibodies to BRAF become accessible to intracellular BRAF.
Positive_regulation (accessible) of BRAF
9) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.71 Pain Relevance 0.41
Peptide P25 on BRAF is specifically recognized by RA patients
Positive_regulation (Peptide) of BRAF associated with rheumatoid arthritis
10) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.00 Pain Relevance 0.58
We have investigated the histopathological features and frequency of BRAF and KRAS2 mutations in 2 patients with PRSS1 mutations (p.A121T, p.R122H) and patients with CP (n = 11).
Spec (investigated) Positive_regulation (mutations) of BRAF
11) Confidence 0.14 Published 2008 Journal Digestion Section Abstract Doc Link 18946221 Disease Relevance 0.52 Pain Relevance 0.16
Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.
Positive_regulation (evaluation) of BRAF associated with chronic pancreatitis
12) Confidence 0.14 Published 2008 Journal Digestion Section Title Doc Link 18946221 Disease Relevance 0.58 Pain Relevance 0.20

General Comments

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