INT15552

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.49
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
medial 1
cerebral cortex 1
brain 1
PVN 1
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
Clonidine 25 99.72 Very High Very High Very High
Morphine 8 99.68 Very High Very High Very High
analgesia 8 99.60 Very High Very High Very High
noradrenaline 7 98.88 Very High Very High Very High
anticonvulsant 1 97.76 Very High Very High Very High
cerebral cortex 4 97.24 Very High Very High Very High
gABA 16 97.16 Very High Very High Very High
agonist 11 96.70 Very High Very High Very High
midbrain 5 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 4 96.88 Very High Very High Very High
Urological Neuroanatomy 2 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of the alpha-2 adrenoceptor antagonist idazoxan (10(-6) M), comparable amounts of tritium were released by the first stimulus and each of the following stimuli at 0.02 Hz.
Localization (released) of alpha-2 associated with antagonist
1) Confidence 0.69 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2838608 Disease Relevance 0 Pain Relevance 0.41
Although [125I]ICYP binding was unaltered, alpha-2 agonists such as clonidine, norepinephrine and UK 14304 [5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline) as well as the alpha-2 antagonists rauwolscine and yohimbine also decreased the K(+)-stimulated release of [3H]-5-HT and phentolamine, an alpha-2 antagonist increased release.
Localization (release) of alpha-2 associated with antagonist, agonist and clonidine
2) Confidence 0.67 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1738111 Disease Relevance 0 Pain Relevance 0.37
Previous autoradiographic studies which have localized alpha-2 adrenoceptors within brain have used tritiated derivatives of clonidine and other alpha-2 adrenergic agonists.
Localization (localized) of alpha-2 in brain associated with agonist and clonidine
3) Confidence 0.48 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3037066 Disease Relevance 0 Pain Relevance 0.24
These findings provide evidence for localization of anatomical substrates which underlie PVN alpha 2-noradrenergic feeding.
Localization (localization) of alpha 2-noradrenergic in PVN
4) Confidence 0.46 Published 1985 Journal Brain Res. Section Abstract Doc Link 4063807 Disease Relevance 0 Pain Relevance 0.64
These results suggest that the reduction of NA release at alpha 2-noradrenergic receptors or antagonism of noradrenaline effects at alpha 1-receptors exerts seizure suppressant effects.
Localization (release) of alpha 2-noradrenergic associated with convulsion and noradrenaline
5) Confidence 0.30 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6274658 Disease Relevance 0.35 Pain Relevance 0.35
Clonidine enhances the release of endogenous gamma-aminobutyric acid through alpha-2 and alpha-1 presynaptic adrenoceptors differentially located in rat cerebral cortex subregions.
Localization (release) of alpha-2 in cerebral cortex associated with cerebral cortex and clonidine
6) Confidence 0.16 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2835479 Disease Relevance 0.05 Pain Relevance 0.99
Pentobarbital induced a desensibilization for alpha 2-receptors (8.3 +/- 0.5 vs 16.0 +/- 1.4 mmol/l Na+) and a sensibilization for alpha 3-receptors (14.4 +/- 0.8 vs 10 +/- 1.3 mmol/l Na+).
Localization (sensibilization) of alpha 2
7) Confidence 0.12 Published 1997 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 9029486 Disease Relevance 0 Pain Relevance 0.11
A probe targeting Gi alpha 2 blocks morphine analgesia, as previously reported, but is inactive against M6G analgesia.
Localization (targeting) of Gi alpha 2 associated with analgesia and morphine
8) Confidence 0.10 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8592651 Disease Relevance 0.09 Pain Relevance 1.72
The effects of pharmacological manipulations of the two subtypes of central alpha-adrenergic receptors, alpha 1 and alpha 2, were tested on in vitro TRH release from medial basal hypothalami containing mainly the ME.
Localization (release) of alpha 2 in medial
9) Confidence 0.07 Published 1985 Journal Endocrinology Section Abstract Doc Link 2986944 Disease Relevance 0 Pain Relevance 0.03
The enhancing effect of both the alpha2 adrenoceptor agonist and antagonist on GABA release, while appearing paradoxical, can be rationalised by actions at distinct subsets of alpha2 adrenoceptors, using a simple model where alpha2A adrenoceptors are localized on the terminals of noradrenergic afferents impinging upon alpha2C adrenoceptor-containing GABAergic striato-nigral neurones.
Localization (localized) of alpha2A associated with gaba, gabaergic, antagonist and agonist
10) Confidence 0.02 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16356632 Disease Relevance 0 Pain Relevance 0.84

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