INT15553

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 2.61
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)
Anatomy Link Frequency
frontal cortex 2
artery 1
neurons 1
nerve 1
Htr1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 54 99.96 Very High Very High Very High
Serotonin 28 99.36 Very High Very High Very High
fluoxetine 47 99.24 Very High Very High Very High
Spinal cord 11 98.32 Very High Very High Very High
sSRI 12 98.08 Very High Very High Very High
antidepressant 4 97.92 Very High Very High Very High
agonist 33 96.48 Very High Very High Very High
noradrenaline 8 96.20 Very High Very High Very High
Dopamine 8 95.88 Very High Very High Very High
antagonist 44 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impotence 10 99.74 Very High Very High Very High
Urological Neuroanatomy 118 99.30 Very High Very High Very High
Hypotension 4 98.50 Very High Very High Very High
Sprains And Strains 2 97.76 Very High Very High Very High
Depression 3 89.92 High High
Hypertension 4 75.00 Quite High
Pressure Volume 2 Under Development 2 56.84 Quite High
Headache 20 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results point out that [125I]ICYP identifies the 5-HT1B receptor, and affinity of compounds for this site predicts action at the 5-HT1B autoreceptor.
Negative_regulation (identifies) of 5-HT1B
1) Confidence 0.41 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1738111 Disease Relevance 0 Pain Relevance 0.34
M) all produced a significant increase in the ratio of evoked IPSC2/IPSC1 (Figure 1c, e, p = 0.003, 0.04, 0.03, n = 21, 7, 14).

5-HT1A, 5-HT1B and 5-HT1D receptor activation inhibits GABAergic synaptic transmission

Negative_regulation (inhibits) of 5-HT1B associated with gabaergic
2) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.32 Pain Relevance 0.60
Blockade of 5-HT1B receptors by intrapallidal application of methiothepin predominantly caused inhibition in GP neurons firing rate.
Negative_regulation (Blockade) of 5-HT1B in neurons
3) Confidence 0.41 Published 2005 Journal Brain Res. Section Abstract Doc Link 15862532 Disease Relevance 0 Pain Relevance 0.31
On the other hand, in the isolated rabbit ear artery sensitized with 16 mmol/l K+, eugenosedin-A antagonized 5-nonyloxytryptamine- and serotonin-induced vasocontractions, indicating that it also blocked 5-HT1B and 5-HT2A receptors.
Negative_regulation (blocked) of 5-HT1B in artery associated with serotonin
4) Confidence 0.41 Published 2004 Journal Pharmacology Section Abstract Doc Link 15118348 Disease Relevance 0.26 Pain Relevance 0.18
Finally, we suggest that the hypotensive effects of eugenosedin-A can be attributed to its multiple actions on the blockade of 5-HT1B, 5-HT2A, alpha and beta1 receptors in both WKY and SHR strains.
Negative_regulation (blockade) of 5-HT1B associated with hypotension and sprains and strains
5) Confidence 0.41 Published 2004 Journal Pharmacology Section Abstract Doc Link 15118348 Disease Relevance 0.35 Pain Relevance 0.16
The obtained results seem to indicate that blockade of 5-HT1B receptors, but not 5-HT1A ones, can facilitate the antidepressant-like effect of paroxetine in the forced swimming test in rats.
Negative_regulation (blockade) of 5-HT1B associated with antidepressant
6) Confidence 0.41 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866716 Disease Relevance 0 Pain Relevance 0.71
These results indicate that both 5-HT1A and 5-HT1B/1D receptors, which function in the rat as inhibitory somatodendritic and nerve terminal autoreceptors, independently regulate hippocampal 5-HT synthesis and must be simultaneously blocked to prevent the inhibition of 5-HT synthesis by selective serotonin reuptake inhibitors which increase 5-HT availability at both nerve terminals in hippocampus and 5-HT cell bodies in the raphe nuclei.
Negative_regulation (blocked) of 5-HT1B in nerve associated with hippocampus, raphe and ssri
7) Confidence 0.41 Published 1999 Journal Synapse Section Abstract Doc Link 10025679 Disease Relevance 0 Pain Relevance 0.71
Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors.
Negative_regulation (blockade) of 5-HT1B associated with impotence and fluoxetine
8) Confidence 0.41 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9085055 Disease Relevance 0.42 Pain Relevance 0.47
Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,635 and GR 127,935.
Negative_regulation (blockade) of 5-HT1B in frontal cortex associated with urological neuroanatomy, serotonin and fluoxetine
9) Confidence 0.41 Published 1997 Journal J. Neurochem. Section Title Doc Link 9048762 Disease Relevance 0.28 Pain Relevance 0.96
The localisation of the non 5-HT1B [125I]GTI binding sites was characterised by blocking the 5-HT1B receptors with 100 nM CP 93129.
Negative_regulation (blocking) of 5-HT1B
10) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.38
In addition, by blocking the 5-HT1B sites with 100 nM CP 93129, the remaining population of [125I]GTI binding sites could be studied and was found to have high affinity for PAPP, rauwolscine and 8-OH-DPAT.
Negative_regulation (blocking) of 5-HT1B
11) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8361548 Disease Relevance 0 Pain Relevance 0.36
These findings are consistent with the detection of mRNA for each of 5-HT1A, 5-HT1B and 5-HT1D receptors in the present study in both male and female rats, although the present study was not designed to examine quantitative gender related differences.
Negative_regulation (receptors) of 5-HT1B
12) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.28 Pain Relevance 0.42
Combined blockade of 5-HT1A and 5-HT1B autoreceptors markedly enhances the actions of serotonin reuptake inhibitors.
Negative_regulation (blockade) of 5-HT1B associated with serotonin
13) Confidence 0.18 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9085055 Disease Relevance 0.40 Pain Relevance 0.44
The present data demonstrate that combined blockade of 5-HT1A and 5-HT1B autoreceptors markedly and selectively potentiates the fluoxetine-induced increase in dialysate levels of 5-HT versus DA and NAD in the FCx of freely moving rats.
Negative_regulation (blockade) of 5-HT1B in FCx associated with dopamine, noradrenaline, urological neuroanatomy and fluoxetine
14) Confidence 0.18 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9048762 Disease Relevance 0.30 Pain Relevance 1.14

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