INT15554

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 1992
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
cerebral cortex 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
Clonidine 13 99.98 Very High Very High Very High
cerebral cortex 3 97.24 Very High Very High Very High
agonist 2 95.30 Very High Very High Very High
gABA 8 92.36 High High
Spinal cord 5 88.56 High High
GABAergic 1 31.24 Quite Low
Serotonin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 51.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although [125I]ICYP binding was unaltered, alpha-2 agonists such as clonidine, norepinephrine and UK 14304 [5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline) as well as the alpha-2 antagonists rauwolscine and yohimbine also decreased the K(+)-stimulated release of [3H]-5-HT and phentolamine, an alpha-2 antagonist increased release.
Positive_regulation (increased) of Localization (release) of alpha-2 associated with antagonist, agonist and clonidine
1) Confidence 0.44 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1738111 Disease Relevance 0 Pain Relevance 0.37
Clonidine enhances the release of endogenous gamma-aminobutyric acid through alpha-2 and alpha-1 presynaptic adrenoceptors differentially located in rat cerebral cortex subregions.
Positive_regulation (enhances) of Localization (release) of alpha-2 in cerebral cortex associated with cerebral cortex and clonidine
2) Confidence 0.11 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2835479 Disease Relevance 0.05 Pain Relevance 0.99

General Comments

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