INT15555

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.35
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLP1) structural molecule activity (PLP1)
Anatomy Link Frequency
plasma 1
cerebrospinal fluid 1
optic 1
PLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
Dismenorea 7 98.04 Very High Very High Very High
Neuritis 8 97.72 Very High Very High Very High
intrathecal 2 96.56 Very High Very High Very High
Multiple sclerosis 4 95.96 Very High Very High Very High
Somatosensory cortex 3 89.12 High High
Pain score 1 78.12 Quite High
phantom limb 2 75.00 Quite High
sSRI 1 69.84 Quite High
Analgesic 1 41.84 Quite Low
Disease Link Frequency Relevance Heat
Pain 17 100.00 Very High Very High Very High
Premenstrual Syndrome 12 99.80 Very High Very High Very High
Optic Neuritis 8 97.96 Very High Very High Very High
Demyelinating Disease 4 95.96 Very High Very High Very High
Disorder Of Lipid Metabolism 10 77.48 Quite High
Atherosclerosis 7 75.92 Quite High
Urological Neuroanatomy 6 50.00 Quite Low
Body Weight 2 39.12 Quite Low
Decapitation 2 8.52 Low Low
Stress 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 2 years PLP exceeded 3 on NAS in 5 individuals (42%), and the remaining 12 patients presented the same PLP as after 1 year.
Localization (presented) of PLP associated with pain
1) Confidence 0.60 Published 1992 Journal Pain Section Abstract Doc Link 1738570 Disease Relevance 1.14 Pain Relevance 1.31
Anti-myelin basic protein and anti-proteolipid protein antibody-secreting cells in the cerebrospinal fluid of patients with acute optic neuritis.
Localization (secreting) of anti-proteolipid protein in cerebrospinal fluid associated with optic neuritis and neuritis
2) Confidence 0.11 Published 1994 Journal Arch. Neurol. Section Title Doc Link 7524468 Disease Relevance 0.10 Pain Relevance 0.19
The aetiology of PMD and PMDD is not known.
Localization (aetiology) of PMD associated with premenstrual syndrome
3) Confidence 0.08 Published 2010 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 20719012 Disease Relevance 0.89 Pain Relevance 0.60
In both cases, sparse labeling was found in SMA, PMd and M1.
Localization (found) of PMd
4) Confidence 0.03 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583161 Disease Relevance 0 Pain Relevance 0.09
Aliquots of the tissue homogenates and plasma were added to perchrolic acid (1 M) and allowed to sit for one hour to release PLP from protein.
Localization (release) of PLP in plasma
5) Confidence 0.03 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.55 Pain Relevance 0
Anti-myelin basic protein, anti-proteolipid protein, and anti-myelin basic protein peptide (amino acid residues 1-20, 63-88, and 89-101) antibody-secreting cells were studied in 20 patients with idiopathic optic neuritis, 20 with optic neuritis as part of multiple sclerosis, and 20 neurological control subjects.
Localization (secreting) of anti-proteolipid protein in optic associated with multiple sclerosis, optic neuritis and neuritis
6) Confidence 0.01 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 8526468 Disease Relevance 0.66 Pain Relevance 0.56

General Comments

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