INT155563

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.12
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain stem 4
Mknk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 275 99.76 Very High Very High Very High
medulla 55 97.88 Very High Very High Very High
interstitial cystitis 2 50.00 Quite Low
cerebral cortex 5 25.76 Quite Low
anesthesia 5 23.28 Low Low
Inflammatory response 5 18.68 Low Low
Disease Link Frequency Relevance Heat
Death 310 99.90 Very High Very High Very High
Poisoning 35 86.84 High High
Pressure Volume 2 Under Development 20 85.52 High High
Apoptosis 10 74.60 Quite High
Interstitial Cystitis 2 50.00 Quite Low
Critical Illness 5 31.88 Quite Low
Middle Cerebral Artery Infarction 5 22.88 Low Low
INFLAMMATION 5 18.32 Low Low
Toxicity 10 5.00 Very Low Very Low Very Low
Overdose 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of MEK1/2, ERK1/2 or MNK1/2 in RVLM sustains central cardiovascular regulation associated with experimental brain stem death
Positive_regulation (Activation) of MNK1 in brain stem associated with rostral ventrolateral medulla and death
1) Confidence 0.54 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.63 Pain Relevance 0.37
Whether Ang II in RVLM plays a pro-life role during brain stem death via activation of the MEK/ERK/MNK cascade, however, awaits documentation.


Positive_regulation (activation) of MNK in brain stem associated with rostral ventrolateral medulla and death
2) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.33 Pain Relevance 0.25
MNK1 activation is inhibited by MEK inhibitor PD98059 [20,21], suggesting that it is an important regulator for MNK activation.
Positive_regulation (activation) of MNK1
3) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.13 Pain Relevance 0.10
Our results demonstrated that activation of MEK1/2, ERK1/2 and MNK1/2 in RVLM plays a preferential pro-life role by sustaining central cardiovascular regulatory functions during brain stem death via upregulation of the NOS I/PKG signaling cascade in RVLM.


Positive_regulation (activation) of MNK1 in brain stem associated with rostral ventrolateral medulla and death
4) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.46 Pain Relevance 0.17
Our results demonstrated that activation of MEK1/2, ERK1/2 and MNK1/2 in RVLM plays a preferential pro-life role by sustaining the central cardiovascular regulatory machinery during brain stem death via upregulation of NOS I/PKG signaling cascade in RVLM.



Positive_regulation (activation) of MNK1 in brain stem associated with rostral ventrolateral medulla and death
5) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2848001 Disease Relevance 0.57 Pain Relevance 0.20
PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased, and AKR1C2 and MKNK1 were increased in interstitial cystitis cases.
Positive_regulation (increased) of MKNK1
6) Confidence 0.09 Published 2008 Journal J. Urol. Section Body Doc Link 18951569 Disease Relevance 0 Pain Relevance 0

General Comments

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