INT155565

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.24
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Efemp2) proteinaceous extracellular matrix (Efemp2)
Anatomy Link Frequency
muscle 6
Schwann cells 2
medial 1
endothelium 1
smooth muscle cells 1
Efemp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 18 88.56 High High
amygdala 9 60.32 Quite High
Spinal cord 31 59.36 Quite High
Sciatic nerve 9 56.88 Quite High
interstitial cystitis 2 50.00 Quite Low
Hippocampus 12 49.60 Quite Low
imagery 45 29.40 Quite Low
ketamine 27 5.00 Very Low Very Low Very Low
anesthesia 27 5.00 Very Low Very Low Very Low
Analgesic 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 115 100.00 Very High Very High Very High
Prostate Cancer 45 100.00 Very High Very High Very High
Sprains And Strains 63 98.96 Very High Very High Very High
Targeted Disruption 244 98.14 Very High Very High Very High
Motor Neuron Diseases 64 97.80 Very High Very High Very High
Disease 104 96.68 Very High Very High Very High
Toxicity 45 96.54 Very High Very High Very High
Muscle Disease 23 94.36 High High
Cleidocranial Dysplasia 9 93.20 High High
Hemorrhage 18 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, arterial pathologies in fibulin-4+/?
Gene_expression (/) of fibulin-4
1) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.39 Pain Relevance 0
It is not clear why fibulin-4+/?
Gene_expression (/) of fibulin-4
2) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0 Pain Relevance 0
7) and the fibulin-4+/?
Gene_expression (/) of fibulin-4
3) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0 Pain Relevance 0
Another difference between the two strains was that the endothelium was often sloughed in the fibulin-4+/?
Gene_expression (/) of fibulin-4 in endothelium associated with sprains and strains
4) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.10 Pain Relevance 0
Sometimes, in the fibulin-4+/?
Gene_expression (/) of fibulin-4
5) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.09 Pain Relevance 0
Localized regions of disorganized extracellular matrix and collagen fibers appeared between 10%–15% of the medial smooth muscle cell junctions in the fibulin-4+/?
Gene_expression (/) of fibulin-4 in medial
6) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0 Pain Relevance 0
As described previously [5], germ line-transmitting dimeric mice generated from embryonic stem cells containing the lacZ-neo cassette in exon-4 of the mouse fibulin-4 locus, were bred with C57BL/6 mice to produce the fibulin-4+/?
Gene_expression (produce) of fibulin-4 in embryonic stem cells
7) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.15 Pain Relevance 0.03
Fibulin-4 is an extracellular matrix protein expressed by vascular smooth muscle cells that is essential for maintaining arterial integrity.
Gene_expression (expressed) of Fibulin-4 in smooth muscle cells
8) Confidence 0.60 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1794134 Disease Relevance 0.16 Pain Relevance 0.04
In fibulin-4+/?
Gene_expression (/) of fibulin-4
9) Confidence 0.59 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.08 Pain Relevance 0
Those expressed extracellularly and with an average expression level at least three-fold greater in BPH RNA pools than in the prostate cancer RNA pools included: CDH13, CHRNB1, COL4A5, EFEMP2, EMP3, F10 (16-fold), FGF2, FGFBP1 (10-fold), IGF1, IGF2 (18-fold), LIPG, RARB, SGCA, SGCD, TGFB1, TGFB3 (14-fold), TGFBR2 and TIMP2 of the “high in BPH, moderate in prostate cancer” group; SMOC1 (26-fold) in the “high in BPH, low in prostate cancer” group; and SCGB3A1 (15-fold) and SCGB1A1 (14-fold) in the “moderate in BPH, low in prostate cancer” group.


Gene_expression (expressed) of EFEMP2 associated with benign prostatic hypertrophy and prostate cancer
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 2.45 Pain Relevance 0
PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased, and AKR1C2 and MKNK1 were increased in interstitial cystitis cases.
Gene_expression (decreased) of EFEMP2
11) Confidence 0.12 Published 2008 Journal J. Urol. Section Body Doc Link 18951569 Disease Relevance 0 Pain Relevance 0
These results indicate that expression of the mutant protein in muscle is not needed to cause motor terminal degeneration in SOD1G93A transgenic mice and that a combination of motor terminals, motor axons and Schwann cells, all of which express mutant protein may be sufficient.



Gene_expression (express) of mutant protein in Schwann cells associated with targeted disruption
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2842435 Disease Relevance 0.36 Pain Relevance 0
These results indicate that expression of the mutant protein in muscle is not needed to cause motor terminal degeneration in SOD1G93A transgenic mice and that a combination of motor terminals, motor axons and Schwann cells, all of which express mutant protein may be sufficient.



Gene_expression (expression) of mutant protein in Schwann cells associated with targeted disruption
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2842435 Disease Relevance 0.39 Pain Relevance 0
Using behavioral tests, Miller et al [15] reached a similar conclusion after reducing expression of mutant protein in muscles of mice that ubiquitously express SOD1G93A.
Gene_expression (expression) of mutant protein in muscles
14) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.36 Pain Relevance 0
If such transgenic fibers exist, however, then the basis of the toxicity must involve features other than expression of the mutant B6.SOD1G93A protein since fibers that did regenerate in transplants but did not cause motor terminal degeneration expressed the mutant protein.
Neg (not) Gene_expression (expressed) of mutant protein associated with targeted disruption and toxicity
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.53 Pain Relevance 0
Taken together, these results suggest that mutant protein expression by both motor neurons and Schwann cells is at least sufficient to enable motor terminal degeneration while expression in either motor neuron or muscle alone is not.
Gene_expression (expression) of mutant protein in muscle
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.07 Pain Relevance 0.03
The reduction was incomplete, however, leaving open the possibility that reduced expression of mutant protein in muscle or a reduced number of expressing fibers is sufficient to cause the motor neuron disease phenotype.
Gene_expression (expression) of mutant protein in motor neuron associated with motor neuron diseases
17) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.37 Pain Relevance 0
In the Wt->SOD1 group, we can not exclude that innervation of muscles that express mutant protein during earlier life intervals (0–80 d) sets in motion degenerative mechanisms that progress despite later innervation of wildtype muscle.
Gene_expression (express) of mutant protein in muscle
18) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.05 Pain Relevance 0
The results of the present study show that expression of the mutant protein in muscle is similarly not sufficient to produce degeneration of motor terminals.
Gene_expression (expression) of mutant protein in muscle
19) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.10 Pain Relevance 0
These results indicate that mutant protein expression in muscle makes no contribution to denervation in SOD1 mice.
Gene_expression (expression) of mutant protein in muscle
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.31 Pain Relevance 0.03

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