INT1556

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1979
Last Reported 2010
Negated 7
Speculated 3
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 3.23
Pain Relevance 14.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Dnahc8) cytoskeleton (Dnahc8) cilium (Dnahc8)
molecular_function (Dnahc8) biological_process (Dnahc8) cytoplasm (Dnahc8)
Anatomy Link Frequency
brain 2
neuronal 1
retina 1
soleus 1
extensor digitorum longus 1
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 141 99.84 Very High Very High Very High
lidocaine 22 99.82 Very High Very High Very High
opioid receptor 16 99.20 Very High Very High Very High
Hippocampus 10 99.08 Very High Very High Very High
antagonist 26 98.36 Very High Very High Very High
withdrawal 18 98.32 Very High Very High Very High
antidepressant 7 98.16 Very High Very High Very High
Dopamine 15 97.92 Very High Very High Very High
mu opioid receptor 2 97.88 Very High Very High Very High
narcan 25 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 15 97.64 Very High Very High Very High
Bordatella Infection 2 96.40 Very High Very High Very High
Targeted Disruption 14 94.36 High High
Sprains And Strains 128 93.76 High High
Opiate Addiction 4 91.76 High High
Anxiety Disorder 5 91.44 High High
Stress 28 90.84 High High
Aging 3 83.36 Quite High
Pain 23 79.72 Quite High
Nociception 6 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Na+,K+-ATPase was more affected by morphine as compared to Mg++-ATPase activity.
Regulation (affected) of ATPase associated with morphine
1) Confidence 0.61 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.39
Morphine up to 10(-3) M had no effect on basal ATPase activities but at 10(-4) M significantly inhibited dopamine-sensitive ATPase activities in vitro.
Neg (no) Regulation (effect) of ATPase associated with dopamine and morphine
2) Confidence 0.61 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.07
Lidocaine did not affect Na+, K+-ATPase, and Ca2+-ATPase activity.
Neg (not) Regulation (affect) of ATPase associated with lidocaine
3) Confidence 0.59 Published 2005 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15840992 Disease Relevance 0.45 Pain Relevance 1.06
Lidocaine did not affect Na+, K+-ATPase, and Ca2+-ATPase activity.
Neg (not) Regulation (affect) of ATPase associated with lidocaine
4) Confidence 0.59 Published 2005 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15840992 Disease Relevance 0.45 Pain Relevance 1.07
These findings strongly demonstrate that cAMP/PKA signaling pathway involves regulation of Na+,K+-ATPase activity after activation of opioid receptors.
Regulation (regulation) of ATPase associated with opioid receptor
5) Confidence 0.59 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0 Pain Relevance 0.81
The regulation of Na+,K+-ATPase activity by morphine was inversely correlated with intracellular cAMP accumulation.
Regulation (regulation) of ATPase associated with morphine
6) Confidence 0.59 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.06 Pain Relevance 1.14
Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.
Regulation (regulation) of ATPase associated with opioid receptor and morphine
7) Confidence 0.59 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16317112 Disease Relevance 0.09 Pain Relevance 0.76
Morphine through mu-opioid receptors and G(i/o) proteins modulates several cellular effector systems; however, the mechanisms involved in the regulation of Na(+),K(+)-ATPase are not well known.
Regulation (regulation) of ATPase associated with mu opioid receptor and morphine
8) Confidence 0.45 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0 Pain Relevance 0.73
The regulation of Na+,K+-ATPase activity by morphine treatment seemed to associate with the alteration in phosphorylation level but not to be relevant to the change in abundance of Na+,K+-ATPase.
Regulation (regulation) of ATPase associated with morphine
9) Confidence 0.43 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0 Pain Relevance 0.94
The goal of this study was to investigate the effects of endomorphin-1 on Na(+),K(+)-ATPase activity in mouse brain synaptosome in vitro, and its antinociceptive interaction with the Na(+),K(+)-ATPase inhibitor ouabain.
Spec (investigate) Regulation (effects) of ATPase in brain associated with antinociceptive
10) Confidence 0.38 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12504785 Disease Relevance 0 Pain Relevance 0.20
Norepinephrine-sensitive ATPase activity was also restored partially in precipitated withdrawal animals.
Regulation (sensitive) of ATPase associated with withdrawal
11) Confidence 0.27 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.33
However, naloxone partially antagonized the morphine inhibition of depamine-sensitive ATPase activity but not norepinephrine-sensitive ATPase activity.
Regulation (sensitive) of ATPase associated with narcan and morphine
12) Confidence 0.27 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.39
On the other hand, co-incubation with naloxone (1 microM), an opioid receptor antagonist, did not significantly modify the effect of WIN55,212-2 and completely failed to modify the effect of triangle up(9)-THC on synaptosomal Na(+),K(+)-ATPase.
Neg (failed) Regulation (modify) of ATPase associated with antagonist, narcan and opioid receptor
13) Confidence 0.21 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.10 Pain Relevance 0.37
None of the treatments used had a significant effect on the ATPase activity or fiber composition of soleus, extensor digitorum longus, or diaphragm muscles, although parallel determinations in collaborating laboratories verified that the hormones had major effects in other systems.
Spec (determinations) Regulation (effect) of ATPase in extensor digitorum longus
14) Confidence 0.20 Published 1989 Journal J Gerontol Section Abstract Doc Link 2527906 Disease Relevance 0.08 Pain Relevance 0.07
Bis selenide did not alter Na(+) K(+) ATPase, MAO-A and MAO-B activities in whole brains of mice.
Neg (not) Regulation (alter) of ATPase in brains
15) Confidence 0.09 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19961893 Disease Relevance 0 Pain Relevance 0.74
Acute and chronic morphine treatment was demonstrated to modulate Na+/K+ ATPase activity in the mouse hippocampus [50].
Regulation (modulate) of ATPase in hippocampus associated with hippocampus and morphine
16) Confidence 0.08 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.56 Pain Relevance 0.65
None of the treatments used had a significant effect on the ATPase activity or fiber composition of soleus, extensor digitorum longus, or diaphragm muscles, although parallel determinations in collaborating laboratories verified that the hormones had major effects in other systems.
Spec (determinations) Regulation (effect) of ATPase in soleus
17) Confidence 0.07 Published 1989 Journal J Gerontol Section Abstract Doc Link 2527906 Disease Relevance 0.08 Pain Relevance 0.07
Loperamide inhibited intestinal Na+, K+-ATPase activity, whilst sucrase activity was unaffected.
Neg (unaffected) Regulation (unaffected) of ATPase
18) Confidence 0.07 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10875545 Disease Relevance 0 Pain Relevance 0.06
For example, one recent report used both QTL and haplotypic analyses to demonstrate that the early phase of the formalin response was dependent on the activity of afferent neuron ATPase activity, presumably related to the ability of the neuron to maintain an electrochemical gradient supporting neuronal firing [15].
Regulation (dependent) of ATPase in neuronal
19) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.61 Pain Relevance 0.44
In addition to being ATP-dependent, Na+/K+-ATPase activity can be regulated by phosphorylation status, regulatory agents (endogenous ouabain-like substances [15, 30, 34] neurotransmitters such as dopamine (inhibitory) and norepinephrine (stimulatory) [42; 159] and hormones such as insulin [48], oxidant stress such as reactive oxygen species (ROS), [67] and by ionic distributions across the membrane [36, 67, 112].
Regulation (regulated) of ATPase associated with stress, dopamine and neurotransmitter
20) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox