INT155661

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bloc1s1) mitochondrion (Bloc1s1)
Anatomy Link Frequency
dorsal horn 2
Bloc1s1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 99.84 Very High Very High Very High
Dorsal horn neuron 1 99.12 Very High Very High Very High
Spinal cord 3 98.04 Very High Very High Very High
Peripheral nerve injury 3 92.76 High High
Hyperalgesia 1 89.60 High High
Lasting pain 2 88.60 High High
Neuropathic pain 2 84.96 Quite High
Inflammation 2 84.12 Quite High
Inflammatory response 1 56.16 Quite High
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 3 92.76 High High
Hyperalgesia 1 89.60 High High
Pain 2 88.60 High High
Neuropathic Pain 2 84.96 Quite High
INFLAMMATION 3 84.12 Quite High
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of NR1 subunit in dorsal horn associated with nmda receptor, dorsal horn neuron and spinal cord
1) Confidence 0.01 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.81 Pain Relevance 0.87

General Comments

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