INT155663

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 2
spinal 1
P2rx4 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 3 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Neuropathic pain 2 99.80 Very High Very High Very High
Inflammation 2 98.00 Very High Very High Very High
Lasting pain 2 93.52 High High
Spinal cord 3 85.64 High High
nMDA receptor 1 77.28 Quite High
Dorsal horn neuron 1 76.56 Quite High
Hyperalgesia 1 72.24 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 3 100.00 Very High Very High Very High
Neuropathic Pain 2 99.80 Very High Very High Very High
INFLAMMATION 3 98.00 Very High Very High Very High
Pain 2 93.52 High High
Hyperalgesia 1 72.24 Quite High
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.
Positive_regulation (Up-regulation) of P2X4 in spinal Positive_regulation (mediates) of Localization (release) of BDNF in microglia associated with neuralgia, nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Title Doc Link 18971468 Disease Relevance 0.84 Pain Relevance 1.25

General Comments

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