INT155667

Context Info Confidence 0.42 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.16 Pain Relevance 0.10

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1) cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)

Anatomy Link Frequency PGE2 2 Gja1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Demyelination 47 77.80 ischemia 25 66.24 Spinal cord 14 56.88 Inflammation 16 50.00 Central nervous system 6 50.00 Acupuncture 3 50.00 tolerance 6 12.04 Dismenorea 4 10.00 Multiple sclerosis 25 5.00 isoflurane 4 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 31 97.36 Reperfusion Injury 21 84.88 Demyelinating Disease 78 77.80 Parkinson's Disease 7 72.76 Death 2 71.48 Cv Unclassified Under Development 24 66.24 Reprotox - General 1 1 59.24 Aging 18 59.20 Hypertension 2 53.84 Increased Venous Pressure Under Development 1 52.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: (1) The times of writhing body (9.43 +/- 3.87 and 10.28 +/- 4.23) were significantly lower and the latency period of writhing body (12.43 +/- 3.46, 11.00 +/- 3.65) were longer in the group A and the group A+IC as compared with (15.43 +/- 5.13, 17.00 +/- 3.87) and (7.57 +/- 1.99, 8.43 +/- 2.57) in the group M and group A+I (P < 0.05), respectively. (2) The levels of Cx43 mR NA level and protein expression of acupoint in the group A+I were significantly lower than those of the group N (P < 0.05). (3) OTR and VPR mRNA in the uterus in the group A and the group A+IC were significantly lower than those in the group M and the group A+I (P < 0.05), with no significant difference between the group M and the group A+I (P > 0.05). (4) As compared with the group M, PGE2 level increased and PGF2alpha level decreased in the group A and the group A+IC (P < 0.05).

Negative_regulation (decreased) of Gene_expression (expression) of Cx43 in PGE2

1) Confidence 0.42 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.06 Pain Relevance 0

Levels of Cx43 (connexin 43), STAT3 (signal transducer and activator of transcription 3), and Sirt 1 (sirtuin), which play a role in cardioprotection, are also decreased.

Negative_regulation (decreased) of Gene_expression (Levels) of Cx43

2) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.77 Pain Relevance 0.03

The expression of both Cx30 and Cx43 was profoundly reduced in both, the LPS lesions (Fig. 3m–t) as well as the experimental NMO lesions (Fig. 1m).

Negative_regulation (reduced) of Gene_expression (expression) of Cx43 associated with neuromyelitis optica

3) Confidence 0.05 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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