INT155667

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
PGE2 2
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Demyelination 47 77.80 Quite High
ischemia 25 66.24 Quite High
Spinal cord 14 56.88 Quite High
Inflammation 16 50.00 Quite Low
Central nervous system 6 50.00 Quite Low
Acupuncture 3 50.00 Quite Low
tolerance 6 12.04 Low Low
Dismenorea 4 10.00 Low Low
Multiple sclerosis 25 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 31 97.36 Very High Very High Very High
Reperfusion Injury 21 84.88 Quite High
Demyelinating Disease 78 77.80 Quite High
Parkinson's Disease 7 72.76 Quite High
Death 2 71.48 Quite High
Cv Unclassified Under Development 24 66.24 Quite High
Reprotox - General 1 1 59.24 Quite High
Aging 18 59.20 Quite High
Hypertension 2 53.84 Quite High
Increased Venous Pressure Under Development 1 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: (1) The times of writhing body (9.43 +/- 3.87 and 10.28 +/- 4.23) were significantly lower and the latency period of writhing body (12.43 +/- 3.46, 11.00 +/- 3.65) were longer in the group A and the group A+IC as compared with (15.43 +/- 5.13, 17.00 +/- 3.87) and (7.57 +/- 1.99, 8.43 +/- 2.57) in the group M and group A+I (P < 0.05), respectively. (2) The levels of Cx43 mR NA level and protein expression of acupoint in the group A+I were significantly lower than those of the group N (P < 0.05). (3) OTR and VPR mRNA in the uterus in the group A and the group A+IC were significantly lower than those in the group M and the group A+I (P < 0.05), with no significant difference between the group M and the group A+I (P > 0.05). (4) As compared with the group M, PGE2 level increased and PGF2alpha level decreased in the group A and the group A+IC (P < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of Cx43 in PGE2
1) Confidence 0.42 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.06 Pain Relevance 0
Levels of Cx43 (connexin 43), STAT3 (signal transducer and activator of transcription 3), and Sirt 1 (sirtuin), which play a role in cardioprotection, are also decreased.
Negative_regulation (decreased) of Gene_expression (Levels) of Cx43
2) Confidence 0.06 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.77 Pain Relevance 0.03
The expression of both Cx30 and Cx43 was profoundly reduced in both, the LPS lesions (Fig. 3m–t) as well as the experimental NMO lesions (Fig. 1m).
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 associated with neuromyelitis optica
3) Confidence 0.05 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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