INT155668

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
endometrium 1
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 38 100.00 Very High Very High Very High
Calcium channel 1 71.84 Quite High
methotrexate 1 69.16 Quite High
Acupuncture 3 50.00 Quite Low
Neuropeptide 6 23.44 Low Low
Ventral tegmentum 3 22.56 Low Low
Dismenorea 4 10.00 Low Low
agonist 24 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Antinociceptive 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Birth 1 98.80 Very High Very High Very High
Autism 6 95.72 Very High Very High Very High
Pre-term Labor 3 88.72 High High
Reprotox - General 1 1 34.48 Quite Low
Erectile Dysfunction 2 19.44 Low Low
Stress 12 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Silencing Cx43 expression of partial acupoint can inhibit effectively the effect of acupuncture through decreasing OTR and VPR in endometrium of the dysmenorrheal rat and adjusting the prostaglandins (PGs) synthesis system, which possibly is one of the mechanisms of acupuncture for treatment of primary dysmenorrhea.


Negative_regulation (decreasing) of OTR in endometrium
1) Confidence 0.50 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0 Pain Relevance 0
Noteworthy is that an antagonist of the oxytocin receptor (Atosiban) is given to delay premature birth [130,131].
Negative_regulation (antagonist) of oxytocin receptor associated with premature birth and antagonist
2) Confidence 0.28 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.28 Pain Relevance 0.12

General Comments

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