INT155681

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.26
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a3) plasma membrane (Slc1a3)
Anatomy Link Frequency
photoreceptors 2
Slc1a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
Glutamate 9 100.00 Very High Very High Very High
Physical dependence 6 100.00 Very High Very High Very High
excitatory amino acid 2 100.00 Very High Very High Very High
narcan 6 95.88 Very High Very High Very High
tolerance 14 87.56 High High
medulla 33 86.96 High High
analgesia 10 84.96 Quite High
Analgesic 2 84.68 Quite High
Inflammatory response 5 72.88 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 6 100.00 Very High Very High Very High
Neurological Disease 1 98.80 Very High Very High Very High
Targeted Disruption 260 98.68 Very High Very High Very High
Ganglion Cysts 8 97.44 Very High Very High Very High
INFLAMMATION 9 72.88 Quite High
Disease 45 50.00 Quite Low
Gliosis 2 29.28 Quite Low
Retina Disease 72 5.00 Very Low Very Low Very Low
Usher Syndrome 72 5.00 Very Low Very Low Very Low
Deafness 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also measured the expression levels (Figure 4C) of six genes in addition to Clrn1 and Thy1: cFos, Slc1a3, Grm1, Rho, Rp1, and Vim.
Negative_regulation (measured) of Gene_expression (expression) of Slc1a3
1) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.10 Pain Relevance 0.04
When compared to expression levels in the WT animal, the loss of photoreceptors resulted in reduced expression of the immediate early gene transcription factor cFos, as well as Slc1a3 and Grm1, a glutamate transporter and receptor, respectively.
Negative_regulation (reduced) of Gene_expression (expression) of Slc1a3 in photoreceptors associated with glutamate
2) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.09 Pain Relevance 0.05
Here we found that the expression of excitatory amino acid transporter 1 and 2 (GLAST, GLT1) was significantly decreased in asymptomatic and symptomatic A53T mice (Figs. 4O-P), indicating that excitotoxicity may occur in A53T mice.


Negative_regulation (decreased) of Gene_expression (expression) of GLAST associated with targeted disruption and excitatory amino acid
3) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.87 Pain Relevance 0.38
This suggested that AQP4 deficiency inhibited the development of morphine physical dependence. (4) Repeated morphine administration down-regulated cerebral glutamate transporter 1 (GLT-1) expression in wild-type mice.
Negative_regulation (inhibited) of Gene_expression (expression) of glutamate transporter 1 associated with glutamate, physical dependence and morphine
4) Confidence 0.08 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.61 Pain Relevance 2.23
This suggested that AQP4 deficiency inhibited the development of morphine physical dependence. (4) Repeated morphine administration down-regulated cerebral glutamate transporter 1 (GLT-1) expression in wild-type mice.
Negative_regulation (down-regulated) of Gene_expression (expression) of glutamate transporter 1 associated with glutamate, physical dependence and morphine
5) Confidence 0.08 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.60 Pain Relevance 2.16

General Comments

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